Insulin-like growth factor II IRES

Insulin-like growth factor II IRES
Predicted secondary structure and sequence conservation of IRES_IGF2
Identifiers
SymbolIRES_IGF2
RfamRF00483
Other data
RNA typeCis-reg; IRES
Domain(s)Eukaryota
GOGO:0043022
SOSO:0000243
PDB structuresPDBe

The insulin-like growth factor II (IGF-II) internal ribosome entry site IRES is found in the 5' UTR of IGF-II leader 2 mRNA. This RNA element allows cap-independent translation of the mRNA and it is thought that this family may facilitate a continuous IGF-II production in rapidly dividing cells during development.[1] Ribosomal scanning on human insulin-like growth factor II (IGF-II) is hard to comprehend due to one open reading frame and the ability for the hormone to fold into a stable structure.[2]

References

  1. ^ Pedersen SK, Christiansen J, Hansen T, Larsen MR, Nielsen FC (April 2002). "Human insulin-like growth factor II leader 2 mediates internal initiation of translation". The Biochemical Journal. 363 (Pt 1): 37–44. doi:10.1042/0264-6021:3630037. PMC 1222448. PMID 11903044.
  2. ^ van der Velden AW, van Nierop K, Voorma HO, Thomas AA (March 2002). "Ribosomal scanning on the highly structured insulin-like growth factor II-leader 1". The International Journal of Biochemistry & Cell Biology. 34 (3): 286–297. doi:10.1016/S1357-2725(01)00116-9. PMID 11849996.
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