PROFILPELAJAR.COM

ITM2A

ITM2A
Identifiers
AliasesITM2A, BRICD2A, E25A, integral membrane protein 2A
External IDsOMIM: 300222; MGI: 107706; GeneCards: ITM2A
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

9452

16431

Ensembl

ENSG00000078596

ENSMUSG00000031239

UniProt

O43736

Q61500

RefSeq (mRNA)

NM_004867
NM_001171581

NM_008409

RefSeq (protein)

NP_001165052
NP_004858

NP_032435

Location (UCSC)Chr X: 79.36 – 79.37 MbChr X: 106.44 – 106.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Integral membrane protein 2A is a protein that in humans is encoded by the ITM2A gene.[5][6][7][8]

Function

The protein encoded by this gene is involved in osteo- and chondrogenic cellular differentiation (the cells which are responsible for the development of bone and cartilage respectively).[6]

ITM2A is also involved in activation of T-cells in the immune system[9] and in myocyte differentiation.[10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000078596 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031239 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pittois K, Wauters J, Bossuyt P, Deleersnijder W, Merregaert J (Mar 1999). "Genomic organization and chromosomal localization of the Itm2a gene". Mamm Genome. 10 (1): 54–6. doi:10.1007/s003359900942. PMID 9892734. S2CID 24117211.
  6. ^ a b Deleersnijder W, Hong G, Cortvrindt R, Poirier C, Tylzanowski P, Pittois K, Van Marck E, Merregaert J (Sep 1996). "Isolation of markers for chondro-osteogenic differentiation using cDNA library subtraction. Molecular cloning and characterization of a gene belonging to a novel multigene family of integral membrane proteins". J Biol Chem. 271 (32): 19475–82. doi:10.1074/jbc.271.32.19475. PMID 8702637.
  7. ^ "Entrez Gene: ITM2A integral membrane protein 2A".
  8. ^ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (July 1998). "Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
  9. ^ Kirchner J, Bevan MJ (July 1999). "Itm2a Is Induced during Thymocyte Selection and T Cell Activation and Causes Downregulation of Cd8 When Overexpressed in Cd4+Cd8+ Double Positive Thymocytes". J. Exp. Med. 190 (2): 217–28. doi:10.1084/jem.190.2.217. PMC 2195576. PMID 10432285.
  10. ^ Van den Plas D, Merregaert J (2004). "Constitutive overexpression of the integral membrane protein Itm2A enhances myogenic differentiation of C2C12 cells". Cell Biol. Int. 28 (3): 199–207. doi:10.1016/j.cellbi.2003.11.019. PMID 14984746. S2CID 28123188.

Further reading


Stub icon

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by adding missing information.

Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.