3FQW, 3FQX
8660
384783
ENSG00000185950
ENSMUSG00000038894
Q9Y4H2
P81122
NM_003749
NM_001081212
NP_003740
NP_001074681
Insulin receptor substrate 2 is a protein that in humans is encoded by the IRS2 gene.[5]
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.[6]
Mice lacking IRS2 have a diabetic phenotype[7] as well as a 40% reduction in brain mass.[8]
IRS2 has been shown to interact with:
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