INSM1
Insulinoma-associated protein 1 is a protein that in humans is encoded by the INSM1 gene.[5][6][7]
Function
Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors.[7][8]
Interactions
INSM1 has been shown to interact with SORBS1.[9]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000173404 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000068154 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Lan MS, Li Q, Lu J, Modi WS, Notkins AL (May 1994). "Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1". The Journal of Biological Chemistry. 269 (19): 14170–4. doi:10.1016/S0021-9258(17)36770-4. PMID 8188699.
- ^ Liu WD, Wang HW, Muguira M, Breslin MB, Lan MS (July 2006). "INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases". The Biochemical Journal. 397 (1): 169–77. doi:10.1042/BJ20051669. PMC 1479746. PMID 16569215.
- ^ a b "Entrez Gene: INSM1 insulinoma-associated 1".
- ^ Mukhopadhyay S, Dermawan JK, Lanigan CP, Farver CF (August 2018). "Insulinoma-associated protein 1 (INSM1) is a sensitive and highly specific marker of neuroendocrine differentiation in primary lung neoplasms: an immunohistochemical study of 345 cases, including 292 whole-tissue sections". Modern Pathology. 32 (1): 100–109. doi:10.1038/s41379-018-0122-7. PMID 30154579. S2CID 52110673.
- ^ Xie J, Cai T, Zhang H, Lan MS, Notkins AL (July 2002). "The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein". Genomics. 80 (1): 54–61. doi:10.1006/geno.2002.6800. PMC 1237014. PMID 12079283.
Further reading
- Goto Y, De Silva MG, Toscani A, Prabhakar BS, Notkins AL, Lan MS (July 1992). "A novel human insulinoma-associated cDNA, IA-1, encodes a protein with "zinc-finger" DNA-binding motifs". The Journal of Biological Chemistry. 267 (21): 15252–7. doi:10.1016/S0021-9258(18)42173-4. PMID 1634555.
- Li Q, Notkins AL, Lan MS (July 1997). "Molecular characterization of the promoter region of a neuroendocrine tumor marker, IA-1". Biochemical and Biophysical Research Communications. 236 (3): 776–81. doi:10.1006/bbrc.1997.7054. PMID 9245732.
- Breslin MB, Zhu M, Notkins AL, Lan MS (February 2002). "Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence". Nucleic Acids Research. 30 (4): 1038–45. doi:10.1093/nar/30.4.1038. PMC 100352. PMID 11842116.
- Zhu M, Breslin MB, Lan MS (March 2002). "Expression of a novel zinc-finger cDNA, IA-1, is associated with rat AR42J cells differentiation into insulin-positive cells". Pancreas. 24 (2): 139–45. doi:10.1097/00006676-200203000-00004. PMID 11854618. S2CID 23037260.
- Xie J, Cai T, Zhang H, Lan MS, Notkins AL (July 2002). "The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein". Genomics. 80 (1): 54–61. doi:10.1006/geno.2002.6800. PMC 1237014. PMID 12079283.
- Breslin MB, Zhu M, Lan MS (October 2003). "NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system". The Journal of Biological Chemistry. 278 (40): 38991–7. doi:10.1074/jbc.M306795200. PMC 1236987. PMID 12890672.
- Zhang T, Liu WD, Saunee NA, Breslin MB, Lan MS (February 2009). "Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest". The Journal of Biological Chemistry. 284 (9): 5574–81. doi:10.1074/jbc.M808843200. PMC 2645817. PMID 19124461.
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