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IFIT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4G1T
Identifiers
Aliases	IFIT2, G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, P54, cig42, interferon induced protein with tetratricopeptide repeats 2, ISG-54
External IDs	OMIM: 147040; MGI: 99449; HomoloGene: 1187; GeneCards: IFIT2; OMA:IFIT2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	89,309,271 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	34,553,819 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; inferior ganglion of vagus nerve; ; trigeminal ganglion; ; subthalamic nucleus; ; visceral pleura; ; white blood cell; ; monocyte; ; external globus pallidus; ; parietal pleura; ; spinal ganglia;
	Top expressed in
	iris; ; mammillary body; ; lumbar spinal ganglion; ; decidua; ; endothelial cell of lymphatic vessel; ; blood; ; ciliary body; ; sciatic nerve; ; medial geniculate nucleus; ; medial dorsal nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; RNA binding;
Cellular component	cytoplasm; cytosol; endoplasmic reticulum;
Biological process	apoptotic process; positive regulation of apoptotic process; response to virus; innate immune response; defense response to virus; negative regulation of protein binding; apoptotic mitochondrial changes; type I interferon signaling pathway; cellular response to interferon-alpha; immune system process;
	Sources:Amigo / QuickGO
Orthologs
	3433
	15958
	ENSG00000119922
	ENSMUSG00000045932
	P09913
	Q64112
	NM_001547
	NM_008332; NM_001355262
	NP_001538
	NP_032358; NP_001342191
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon-induced protein with tetratricopeptide repeats 2 (commonly termed IFIT2) is a protein that in humans is directed to be produced by the IFIT2 gene.^[5]^[6]^[7] Previously, this gene was termed the G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, or P54 gene and the protein that it directs to be produced was termed the G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, or P54 protein.^[8] The IFIT2 gene is one of the many genes that are stimulated by type 1 interferons to form their messenger RNAs and thereby their product proteins. Consequently, the IFIT2 gene is classified as one the many type 1 interferon-stimulated genes.^[8]^[9]^[10]

Clinical significance

IFIT2 may play a role in preventing tumor progression.^[11] Indeed, IFIT2 gene has been detected progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.^[12] For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.^[12]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119922 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045932 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wathelet MG, Szpirer J, Nols CB, Clauss IM, De Wit L, Islam MQ, Levan G, Horisberger MA, Content J, Szpirer C (Nov 1988). "Cloning and chromosomal location of human genes inducible by type I interferon". Somat Cell Mol Genet. 14 (5): 415–26. doi:10.1007/BF01534709. PMID 3175763. S2CID 42406993.
^ Wathelet MG, Clauss IM, Content J, Huez GA (Jun 1988). "The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family". FEBS Lett. 231 (1): 164–71. Bibcode:1988FEBSL.231..164W. doi:10.1016/0014-5793(88)80724-5. PMID 3360121. S2CID 22937671.
^ "Entrez Gene: IFIT2 interferon-induced protein with tetratricopeptide repeats 2".
^ ^a ^b Mears HV, Sweeney TR (November 2018). "Better together: the role of IFIT protein-protein interactions in the antiviral response". The Journal of General Virology. 99 (11): 1463–1477. doi:10.1099/jgv.0.001149. PMID 30234477.
^ Zhou X, Michal JJ, Zhang L, Ding B, Lunney JK, Liu B, Jiang Z (2013). "Interferon induced IFIT family genes in host antiviral defense". International Journal of Biological Sciences. 9 (2): 200–8. doi:10.7150/ijbs.5613. PMC 3584916. PMID 23459883.
^ Lang R, Li H, Luo X, Liu C, Zhang Y, Guo S, Xu J, Bao C, Dong W, Yu Y (2022). "Expression and mechanisms of interferon-stimulated genes in viral infection of the central nervous system (CNS) and neurological diseases". Frontiers in Immunology. 13: 1008072. doi:10.3389/fimmu.2022.1008072. PMC 9618809. PMID 36325336.
^ Lai KC, Chang KW, Liu CJ, Kao SY, Lee TC (2008). "IFN-induced protein with tetratricopeptide repeats 2 inhibits migration activity and increases survival of oral squamous cell carcinoma". Mol. Cancer Res. 6 (9): 1431–9. doi:10.1158/1541-7786.MCR-08-0141. PMID 18819931.
^ ^a ^b Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. hdl:11392/2066612. PMID 25205602. S2CID 24986454.

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Wathelet MG, Clauss IM, Content J, Huez GA (1988). "Regulation of two interferon-inducible human genes by interferon, poly(rI).poly(rC) and viruses". Eur. J. Biochem. 174 (2): 323–9. doi:10.1111/j.1432-1033.1988.tb14101.x. PMID 2454816.
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Terenzi F, Hui DJ, Merrick WC, Sen GC (2006). "Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56". J. Biol. Chem. 281 (45): 34064–71. doi:10.1074/jbc.M605771200. PMID 16973618.
Saha S, Sugumar P, Bhandari P, Rangarajan PN (2006). "Identification of Japanese encephalitis virus-inducible genes in mouse brain and characterization of GARG39/IFIT2 as a microtubule-associated protein". J. Gen. Virol. 87 (Pt 11): 3285–9. doi:10.1099/vir.0.82107-0. PMID 17030862.
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