Humoral immune deficiencies are conditions which cause impairment of humoral immunity, which can lead to immunodeficiency. It can be mediated by insufficient number or function of B cells, the plasma cells they differentiate into, or the antibody secreted by the plasma cells.[7] The most common such immunodeficiency is inherited selective IgA deficiency, occurring between 1 in 100 and 1 in 1000 persons, depending on population. They are associated with increased vulnerability to infection, but can be difficult to detect (or asymptomatic) in the absence of infection.[citation needed]
Signs/symptoms of humoral immune deficiency depend on the cause, but generally include signs of infection such as:[1]
Cause of this deficiency is divided into primary and secondary:
In terms of diagnosis of humoral immune deficiency depends upon the following:[5][6]
Treatment for B cell deficiency (humoral immune deficiency) depends on the cause, however generally the following applies:[5]
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peripheral: Purine nucleoside phosphorylase deficiency
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