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Human Nature
Human Nature
	Film documentary cover
Directed by	Adam Bolt
Written by	Adam Bolt, Regina Sobel
Produced by	Greg Boustead, Elliot Kirschner, Dan Rather, Sarah Goodwin, Meredith DeSalazar
Cinematography	Derek Reich
Edited by	Regina Sobel, Steve Tyler
Music by	Keegan DeWitt
Production; companies	News and Guts Films, The Wonder Collaborative
Release date	March 10, 2019 (SXSW);
Running time	107 minutes
Country	United States
Language	English
Box office	$5,834

Human Nature is a 2019 documentary film directed by Adam Bolt and written by Adam Bolt and Regina Sobel. Producers of the film include Greg Boustead, Elliot Kirschner and Dan Rather.^[1]

The film describes the gene editing process of CRISPR (an acronym for "Clustered Regularly Interspaced Short Palindromic Repeats"),^[4] and premiered in Austin, Texas at the South by Southwest film conference and festival on March 10, 2019.^[5]^[4]

Synopsis

Human Nature is a film documentary which presents an in-depth description of the gene editing process of CRISPR, and its possible implications. The film includes the perspective of the scientists who invented the process, and of the genetic engineers who are applying the process. The CRISPR process, a 2013 breakthrough in biology, provides a way of controlling the basic genetic processes of life.

In addition, the film documentary considers several relevant questions including, How will this new gene-editing ability change our relationship with nature? and, What will this new gene-editing ability mean for human evolution? The film, in beginning to answer such questions, presents a review of the distant past and takes an educated look into the future.

The film features the story of David Sanchez, a young man with sickle cell disease.^[6] He is first featured in the hospital, sharing his experience as he gets a red blood cell transfusion. This treatment is currently one of the only available for people with sickle cell to help manage severe pain crises. Geneticists Tshaka Cunningham, Ph.D. and Matt Porteus, M.D. discuss the prospect of using CRISPR to treat sickle cell disease at its genetic source. Porteus is set to start a clinical trial at Stanford University using CRISPR to treat sickle cell disease.^[7] At the end of the film, Sanchez speaks specifically about the role that sickle cell has had in shaping who he is today, stating “I don’t think I’d be me.”

Participants

The documentary film includes the following notable participants (alphabetized by last name):

David Baltimore – American biologist
Matthew Porteus – American researcher
Jill Banfield – American researcher
Rodolphe Barrangou – American researcher
Alta Charo – American bioethicist
Emmanuelle Charpentier – French microbiologist
George M. Church – American geneticist
Tshaka Cunningham – American researcher
George Q. Daley – American hematologist
Jennifer Doudna – American biochemist
Hank Greely – American lawyer
Ian Hodder – British archaeologist
Stephen Hsu – American physicist
Francisco Mojica – Spanish microbiologist
Ryan Phelan – Australian journalist
Antonio Regalado
David Sanchez
Dolores Sanchez
Fyodor Urnov – Russian geneticist
Ethan Weiss
Palmer Weiss
Ruthie Weiss
Luhan Yang--->
Fyodor Urnov – Russian-born biomedical researcher
Feng Zhang – American biochemist

Reviews and criticism

According to film reviewer Devindra Hardawar, writing in Engadget, the film is "a fascinating primer about what led to the discovery of the [CRISPR] tool, and an exploration of the role it may have in our society. It's hopeful about CRISPR's ability to help us fix diseases that have plagued humans for millennia, while also questioning if we're ready to make genetic changes that'll affect us for generations to come."^[1] Reviewer Danielle Solzman writes, "There’s a lot of science involved here. I can't stop but grow cautious when it comes to the Jurassic Park [film] comparisons. At the same time, I also want scientists to push for finding cures to cancer, MS, sickle cell anemia, etc. Maybe gene editing is one possible solution as Human Nature shows."^[8] Film reviewer Sam Machkovech of Ars Technica asks, "[Does this film describe] the future of health? The future of a ... nightmare? By anchoring both of those extremes with a funny, human touch, Human Nature made me feel comfortable with a landing point somewhere closer to the middle."^[4] Reviewer Sean Boelman notes, "Overall, Human Nature [is] an interesting and effective documentary. If you are a fan of science-oriented films, this is not one you will want to miss."^[9]