From 1949 to 1961, Kuo worked as a research associate, later a senior specialist, and finally the project director on the Hurricane Project at the Massachusetts Institute of Technology (MIT). He was Professor Emeritus at the Department of Geophysical Sciences at the University of Chicago.
Kuo developed important mathematical tools to describe the complex circulation patterns of atmospheric activity. He helped to mathematically model the birth of a tropical cyclone (hurricane). Kuo's work is an important part of the theoretical foundation for modern meteorology.[1] He is considered as a member of the Chicago School of Meteorology, which started from Carl-Gustaf Rossby.[2]