House on Old Lonesome Road is the fifty-fourth studio album by American country music singer Conway Twitty. It was released in 1989 on MCA Records, and features the hit "She's Got a Single Thing in Mind", which Allmusic's Jason Ankeny called "the energizing hit which reaffirmed Twitty's standing among the era's country's giants."
"Play, Ruby, Play" was later released as a single by Clinton Gregory.