Two highways approach Hospital Bend from the City Bowl: the N2, known as Nelson Mandela Boulevard, from the Foreshore; and the M3, known as Phillip Kgosana Drive, from Gardens. They merge west of the hospital, with the outward-bound lanes of the M3 passing on a bridge over the N2, to form a freeway of five lanes in each direction. This freeway curves around the southern side of the hospital and past the UCT Medical School before dividing again. The N2, now known as Settlers Way, goes east towards Cape Town International Airport and the Cape Flats; the M3, now known as Rhodes Drive, goes south towards the University of Cape Town, the Southern Suburbs and Muizenberg. Ramps allow vehicles to travel between Settlers Way and Rhodes Drive.
The space between the main carriageways on the Bend accommodate ramps connecting Anzio Road (an access road for the hospital) with Rhodes Drive, and a ramp allowing travel from Anzio Road to the city-bound carriageway.
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