She married her cousin Henry Casimir II, Prince of Nassau-Dietz, in 1683, at the age of 17. When Henry Casimir died in 1696, she became regent for their son, John William Friso, who succeeded to his father's titles. Henriëtte Amalia von Anhalt-Dessau died in 1726 at the age of 59; she was buried in Dietz.
Hendrik Casimir II and Henriëtte Amalia had nine children:
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