Cloke joined the Department of Geography at King's College London. She was part of the Europeanizing Flood Forecasting program, which looked at flood forecasting and management in the European Union.[5]
She joined the University of Reading in 2012, where she is a professor of hydrology.[6] Cloke co-directs the Water@Reading group, which concentrates on water science, policy and societal impacts.[7] She is the Director of the Natural Environment Research Council programme Flooding from Intense Rainfall.[8] She is interested in flood forecasting and risk management, leading the project TENDERLY (Towards END-to End flood forecasting and a tool for ReaL-time catchment susceptibilitY).[8] She works with the Met Office, Environmental Agency and the European Centre for Medium-Range Weather Forecasts (ECMWF).[9] Cloke's Global Flood Awareness System is a partnership between the European Commission and the ECMWF, and provides hydrological monitoring and forecasting that is independent of political boundaries.[10] She was also involved with the Natural Environment Research Council projects Susceptibility of catchments to INTense RAinfall and flooding (SINATRA) and Improving Predictions of Drought for User Decision-Making (IMPETUS).[11][12] Since climate change will make flooding more probable, Cloke says that we should start to take precautions to protect homes and livelihoods.[13]
Cloke's research helps policymakers make better decisions about flood preparation.[14][15] She has discussed the problems with the United Kingdom's flood defence systems.[16][17] She called for the National Flood Resilience Review to evaluate how flood risks are likely to change in different locations across the United Kingdom.[18] She is supported by the European CommissionHorizon 2020 programme. In 2019 Cloke created IMPREXive, a game that allowed players to control flood forecasting during a deluge.[19] The information provided to the players is not always correct; and decisions must be made to keep cities safe.[19]