From 2019 to 2022, Bruins Slot was a member of the provincial executive of Utrecht, in which she was in charge of nature, agriculture, soil and water, sport and governance.[4]
In February 2024, she stated that Israel's planned assault on Rafah was "unjustifiable".[5]
In April 2024 the European Commission co-hosted a conference on "restoring justice for Ukraine" in The Hague. Significant contributors were Slot as the Dutch Minister of Foreign Affairs, the Ukrainian Minister of Foreign Affairs, Dmytro Kuleba and the Commissioner for Justice, Didier Reynders.[6]