A control pitcher, Wyse was a sinkerballer and a curve specialist. Wyse was nicknamed "Hooks" in acknowledgment of his curveball, described by Wyse biographer Gregory Wolf as "knee-buckling". Wyse suffered a spinal injury that kept him from serving in World War II. As a result, he wore a corset at times to pitch.[1]
Wyse debuted for the Chicago Cubs on September 7, 1942, and would remain a Cub thru the 1947 season. Wyse also pitched in the American League with the Philadelphia Athletics and Washington Senators for parts of two seasons, playing his final game in the major leagues on June 14, 1951.
His most productive season came in 1945, when he helped the Cubs win the National Leaguepennant after going 22–10 with a 2.68 ERA. During that season he was, for his first and only time, selected as an All-Star[2] and pitched a one-hitter on April 28 against the Pittsburgh Pirates. His potential no-hitter was broken up by Bill Salkeld, who singled in the 8th inning with one out. He would finish seventh in the 1945 National League Most Valuable Player vote.[3]
Wyse would pitch and be credited with a loss in the second game of the World Series. He relieved in Games 6 and 7. Until Jon Lester pitched in the first inning of the 2016 World Series, Wyse was the last Cubs' pitcher to appear in a World Series game. The 1945 World Series would be Wyse's only postseason appearance.