Altıntop started his professional career in the local German club Wattenscheid 09 along with his brother. As successful performances grabbed the attention of bigger clubs, Altıntop was transferred to 1. FC Kaiserslautern, and his brother to Schalke 04. Altıntop, who played as a striker, finished third highest scorer in the Bundesliga for the 2005–06 season with 20 goals.
At the end of that season he joined his brother at Schalke 04 on a free transfer. However, after only one season, his brother Hamit Altıntop joined Bayern Munich on another free deal. On 27 January 2010, he terminated his contract with Schalke 04 and joined Eintracht Frankfurt.[3]
After Eintracht Frankfurt were relegated in the 2010–11 season, Altıntop was transferred to Turkish side Trabzonspor signing a three-year contract.
Altıntop joined FC Augsburg in summer 2013.[4] He finished the 2016–17 season with 6 goals and 2 assists in 31 matches.[4] At the end of the season he announced his decision not to renew his contract with club. In this time at Augsburg, he made 116 appearances in the Bundesliga scoring 20 goals and contributing 12 assists.[4]
On 31 January 2018, Altintop returned to 1. FC Kaiserslautern on a year-and-a-half contract until 2019.[6][7] However, in June 2018, he terminated his contract with the club and announced his retirement.[8]
By July 2020, Altıntop became an assistant coach for Bayern Munich U16 team,[12] and the following season, he was appointed as head coach of the U17 team. He later transitioned to a role as a trainer scout for Bayern Munich. In March 2023, Altıntop was appointed as the sporting director of the FC Bayern Campus.[13] Altıntop resigned from his post at Bayern Munich on July 31st, 2024. [14]