The attack consists of making the server print a carriage return (CR, ASCII0x0D) line feed (LF, ASCII 0x0A) sequence followed by content supplied by the attacker in the header section of its response, typically by including them in input fields sent to the application. Per the HTTP standard (RFC 2616), headers are separated by one CRLF and the response's headers are separated from its body by two. Therefore, the failure to remove CRs and LFs allows the attacker to set arbitrary headers, take control of the body, or break the response into two or more separate responses—hence the name.
Prevention
The generic solution is to URL-encode strings before inclusion into HTTP headers such as Location or Set-Cookie.
Typical examples of sanitization include casting to integers or aggressive regular expression replacement. Most modern server-side scripting languages and runtimes, like PHP since version 5.1.2[1] and Node.js since 4.6.0 (previous versions supported it, but the protection could've been bypassed, which was discovered in 2016)[2] as well as Web frameworks, such as Django since version 1.8.4[3] support sanitization of HTTP responses against this type of vulnerability.