HSI may refer to:

• Croatian Syrmian Initiative, a political party in Serbia (Croatian: Hrvatska srijemska inicijativa)
• Hispanic-serving institution, an American college designation
• Homeland Security Investigations, an American law enforcement agency
• Humane Society International, an animal welfare organization

• HSI color space, in computing
• Heterosubtypic immunity, in medicine
• High Speed Interconnect, a computer chip
• Horizontal shaft impactor, a rock crusher
• Horizontal situation indicator, an aircraft instrument
• Hurricane Severity Index
• Hyperspectral imaging

• HSI (track team)
• Croatian World Games (Croatian: Hrvatske svjetske igre), multi-sport international event
• Icelandic Handball Association (Icelandic: Handknattleikssamband Íslands, HSÍ)

• Hsi (surname), various Chinese surnames, romanized Xi in Pinyin
• Hang Seng Index, a stock market index
• Hastings Municipal Airport, Nebraska, United States

• HS1 (disambiguation) ('HS' and the digit '1')
• Xi (disambiguation) — Xi and Hsi are different transliterations of the same sound in Chinese

This disambiguation page lists articles associated with the title HSI.
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