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HS3ST3B1

HS3ST3B1
Identifiers
AliasesHS3ST3B1, 30ST3B1, 3OST3B1, 3-OST-3B, h3-OST-3B, heparan sulfate-glucosamine 3-sulfotransferase 3B1
External IDsOMIM: 604058; MGI: 1333853; GeneCards: HS3ST3B1
Enzyme activity
EC #BRENDAExPASyKEGGMetaCyc
2.8.2.30↗↗↗↗
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

9953

54710

Ensembl

ENSG00000125430

ENSMUSG00000070407

UniProt

Q9Y662

Q9QZS6

RefSeq (mRNA)

NM_006041

NM_018805

RefSeq (protein)

NP_006032

NP_061275

Location (UCSC)Chr 17: 14.3 – 14.35 MbChr 11: 63.78 – 63.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 is an enzyme that in humans is encoded by the HS3ST3B1 gene.[5][6] Heparan sulfate biosynthetic enzymes are key components in generating myriad distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity ( HS3ST3A1). The Sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1 and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125430 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070407 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Shworak NW, Liu J, Petros LM, Zhang L, Kobayashi M, Copeland NG, Jenkins NA, Rosenberg RD (Mar 1999). "Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci". J Biol Chem. 274 (8): 5170–84. doi:10.1074/jbc.274.8.5170. PMID 9988767.
  6. ^ a b "Entrez Gene: HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1".

Further reading


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