HRE usually refers to the Holy Roman Empire, a historic political entity in Central Europe.

HRE may also refer to:

• Hanno R. Ellenbogen Citizenship Award, an annual award ceremony
• Hrê language, a North Bahnaric language spoken in Vietnam, mainly by the H're people
• H're people, an ethnic group of Vietnam who largely speak the Hrê language
• Harare International Airport, in Zimbabwe
• Holy Roman Emperor, the leader of the Holy Roman Empire, nominally in charge of these territories
• Hormone response element, a DNA sequence within genes, involved in the regulation of the genes' expression
• Hudson River Expressway, a proposed highway in New York state, United States
• Human rights education
• Hypo Real Estate, a German holding company and commercial property lender
• Hybrid Rocket Engine, a type of rocket engine with fuel and oxidizer in different states
• Waco HRE, an American biplane
• HRE, a Rockwell scale of hardness

This disambiguation page lists articles associated with the title HRE.
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