HOOK3

HOOK3
Identifiers
Aliases	HOOK3, HK3, hook microtubule-tethering protein 3, hook microtubule tethering protein 3
External IDs	OMIM: 607825; MGI: 2443554; GeneCards: HOOK3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5J8E
Gene location (Human)
Chr.	Chromosome 8 (human)
End	43,030,535 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	26,609,252 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; sural nerve; ; tendon of biceps brachii; ; epithelium of colon; ; pancreatic epithelial cell; ; corpus callosum; ; endothelial cell; ; buccal mucosa cell; ; internal globus pallidus; ; deltoid muscle;
	Top expressed in
	otolith organ; ; utricle; ; knee joint; ; tibialis anterior muscle; ; hand; ; triceps brachii muscle; ; vastus lateralis muscle; ; Rostral migratory stream; ; tail of embryo; ; foot;
	More reference expression data
	n/a
Gene ontology
Molecular function	microtubule binding; protein binding; identical protein binding; dynein light intermediate chain binding; dynactin binding; dynein light chain binding; dynein intermediate chain binding;
Cellular component	HOPS complex; FHF complex; cis-Golgi network; centriolar satellite; microtubule; cytoskeleton; cytosol; pericentriolar material; cytoplasm; Golgi apparatus; centrosome;
Biological process	endosome to lysosome transport; endosome organization; neuronal stem cell population maintenance; Golgi localization; early endosome to late endosome transport; cytoplasmic microtubule organization; protein transport; lysosome organization; microtubule anchoring at centrosome; interkinetic nuclear migration; negative regulation of neurogenesis; protein localization to centrosome; cytoskeleton-dependent intracellular transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	84376
	320191
	ENSG00000168172
	ENSMUSG00000037234
	Q86VS8
	Q8BUK6
	NM_032410
	NM_207659
	NP_115786
	NP_997542
	Wikidata
View/Edit Human	View/Edit Mouse

Protein Hook homolog 3 is a protein that in humans is encoded by the HOOK3 gene.^[5]^[6]

Function

Hook proteins are cytosolic coiled coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168172 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037234 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kramer H, Phistry M (Mar 1999). "Genetic analysis of hook, a gene required for endocytic trafficking in drosophila". Genetics. 151 (2): 675–84. doi:10.1093/genetics/151.2.675. PMC 1460498. PMID 9927460.
^ ^a ^b "Entrez Gene: HOOK3 hook homolog 3 (Drosophila)".

Walenta JH, Didier AJ, Liu X, Krämer H (2001). "The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins". J. Cell Biol. 152 (5): 923–34. doi:10.1083/jcb.152.5.923. PMC 2198811. PMID 11238449.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Shotland Y, Krämer H, Groisman EA (2003). "The Salmonella SpiC protein targets the mammalian Hook3 protein function to alter cellular trafficking". Mol. Microbiol. 49 (6): 1565–76. doi:10.1046/j.1365-2958.2003.03668.x. PMID 12950921. S2CID 30972454.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kaiser F, Kaufmann SH, Zerrahn J (2004). "IIGP, a member of the IFN inducible and microbial defense mediating 47 kDa GTPase family, interacts with the microtubule binding protein hook3". J. Cell Sci. 117 (Pt 9): 1747–56. doi:10.1242/jcs.01039. PMID 15075236. S2CID 294834.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Simpson F, Martin S, Evans TM, et al. (2005). "A novel hook-related protein family and the characterization of hook-related protein 1". Traffic. 6 (6): 442–58. doi:10.1111/j.1600-0854.2005.00289.x. PMID 15882442. S2CID 25389776.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Sano H, Ishino M, Krämer H, et al. (2007). "The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A." J. Biol. Chem. 282 (11): 7973–81. doi:10.1074/jbc.M611537200. PMID 17237231.
Ciampi R, Giordano TJ, Wikenheiser-Brokamp K, et al. (2007). "HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma". Endocr. Relat. Cancer. 14 (2): 445–52. doi:10.1677/ERC-07-0039. PMID 17639057.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168172 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037234 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9927460-5] Kramer H, Phistry M (Mar 1999). "Genetic analysis of hook, a gene required for endocytic trafficking in drosophila". Genetics. 151 (2): 675–84. doi:10.1093/genetics/151.2.675. PMC 1460498. PMID 9927460.

[entrez-6] "Entrez Gene: HOOK3 hook homolog 3 (Drosophila)".

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HOOK3

Function

References

Further reading

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