PROFILPELAJAR.COM

HNRNPD
Available structures
PDB	Ortholog search: D6RF44 PDBe D6RF44 RCSB
List of PDB id codes
	1HD0, 1HD1, 1IQT, 1WTB, 1X0F, 2Z5N
Identifiers
Aliases	HNRNPD, AUF1, AUF1A, HNRPD, P37, hnRNPD0, heterogeneous nuclear ribonucleoprotein D
External IDs	OMIM: 601324; MGI: 101947; HomoloGene: 22410; GeneCards: HNRNPD; OMA:HNRNPD - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	82,374,503 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	100,126,797 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; epithelium of nasopharynx; ; tendon of biceps brachii; ; pylorus; ; endometrium; ; gingival epithelium; ; lactiferous duct; ; germinal epithelium; ; tonsil;
	Top expressed in
	tail of embryo; ; genital tubercle; ; epiblast; ; ventricular zone; ; mandibular prominence; ; maxillary prominence; ; neural layer of retina; ; abdominal wall; ; ganglionic eminence; ; somite;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	telomeric DNA binding; protein binding; minor groove of adenine-thymine-rich DNA binding; mRNA binding; histone deacetylase binding; transcription factor binding; chromatin binding; mRNA 3'-UTR AU-rich region binding; DNA binding; nucleic acid binding; RNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding;
Cellular component	cytoplasm; cytosol; extracellular exosome; nucleoplasm; nucleus; synapse; ribonucleoprotein complex;
Biological process	response to electrical stimulus; hepatocyte dedifferentiation; cellular response to amino acid stimulus; positive regulation of transcription, DNA-templated; response to estradiol; mRNA stabilization; response to rapamycin; cellular response to putrescine; cerebellum development; negative regulation of gene expression; mRNA splicing, via spliceosome; positive regulation of translation; RNA processing; liver development; transcription, DNA-templated; regulation of circadian rhythm; response to calcium ion; response to sodium phosphate; 3'-UTR-mediated mRNA destabilization; regulation of mRNA stability; cellular response to nitric oxide; rhythmic process; cellular response to estradiol stimulus; brain development; RNA catabolic process; circadian regulation of translation; regulation of transcription, DNA-templated; positive regulation of gene expression; mRNA transcription by RNA polymerase II; positive regulation of telomere capping; positive regulation of telomerase RNA reverse transcriptase activity; regulation of telomere maintenance; RNA metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	3184
	11991
	ENSG00000138668
	ENSMUSG00000000568
	Q14103
	Q60668
	NM_031370; NM_001003810; NM_002138; NM_031369
	NM_001077265; NM_001077266; NM_001077267; NM_007516
	NP_001003810; NP_002129; NP_112737; NP_112738
	NP_001070733; NP_001070734; NP_001070735; NP_031542
	Wikidata
View/Edit Human	View/Edit Mouse

Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) also known as AU-rich element RNA-binding protein 1 (AUF1) is a protein that in humans is encoded by the HNRNPD gene.^[5]^[6] Alternative splicing of this gene results in four transcript variants.

Function

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). The interaction sites on the RNA are frequently biased towards particular sequence motifs.^[7] These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability.^[6]