HMS Defence was ordered on 23 March 1809 and laid down in May 1812 at Chatham Dockyard. She was launched on 25 April 1815 and served as a 74-gun third-rate ship of the line.
In 1849, she was converted to serve as a prison ship. On 14 July 1857, Defence was badly damaged by an accidental fire at Woolwich, likely caused by spontaneous combustion in a recently delivered load of coal.[2] The fire was extinguished by scuttling the ship, and the remains were subsequently broken up later that year.[3]