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major histocompatibility complex, class II, DR15
Haplotypes groups	DRA01:DRB11501 - to - DRA01:DRB11505 DRA01:DRB11507
Structure (See HLA-DR)
Identifiers	alpha *0101
Symbol(s)	HLA-DRA^{[permanent dead link‍]}
EBI-HLA	DRA*0101
Identifiers	beta 1 1501 to 1505 *1507
Symbol(s)	HLA-DRB1^{[permanent dead link‍]}
EBI-HLA	DRB1*1501
EBI-HLA	DRB1*1502
EBI-HLA	DRB1*1503
EBI-HLA	DRB1*1504
EBI-HLA	DRB1*1505
EBI-HLA	DRB1*1507
Shared data
Locus	chr.6 6p21.31

HLA-DR15 (DR15) is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high levels from Ireland to Central Asia. DR15 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR16 antigens.

Serology

DR15, DR2 and other serotype recognition of some DRB1*15 alleles^[1]
DRB1*	DR15	DR2	DR16	Sample
allele	%	%	%	size (N)
1501	76	23		6428
1502	77	16		676
1503	81	13		286
1504	>50			1
1505	>25			2
1507	>50			1

Serotypes are unknown for the following alleles: DRB1*1506, *1508 to *1516, *1518 to *1522. DRB1*1517N is a null.

Alleles

Disease associations

DR15 is positively associated Goodpasture syndrome,^[2] early age onset multiple sclerosis,^[3] pernicious anaemia,^[4] sarcoidosis,^[5] hypocretin deficiency associated narcolepsy^[6]^[7] and a predisposition for postmenopausal osteoporosis.^[8]

DRB1*1501 is positively associated with Goodpasture syndrome,^[9]^[10] juvenile rheumatoid arthritis,^[11] allergic bronchopulmonary aspergillosis,^[12] multiple sclerosis,^[13] systemic lupus erythematosus,^[14] cervical cancer (human papillomavirus infection),^[15] Sjögren syndrome associated with systemic lupus erythematosus,^[16] and intermediate uveitis.^[17]

DRB1*1502 is associated with systemic lupus erythematosus,^[18] systemic sclerosis (SSc) & anti-topoisomerase antibodies.^[19]

DRB1*1503 is associated with Chaga's cardiomyopathy,^[20] allergic bronchopulmonary aspergillosis,^[12] multiple sclerosis,^[13] cervical cancer (human papillomavirus infection).^[21]

Extended linkage

DRB1*15:DQA1*0102:DQB1*0602 haplotype us associated with cervical cancer risk in (human papillomavirus infection)^[21]

DRB1*1502:DQA1*????:DQB1*0501 haplotype is associated with systemic lupus erythematosus^[18]

Genetic linkage

Serotypes	DRA	DRB1	DRB5
DR15 Haplotypes
DR15(2)-DR51	*0101	*1501	*0101
	*0101	*1502	*0101
	*0101	*1503	*0101
	*0101	*1504	*0101
	*0101	*1505	*0101
	*0101	*1507	*0101
	DQA1	DQB1	DRB1
DR15(2)-DQ6(6.2, 1)	*0102	*0602	*1501
DR15(2)-DQ6(6.1, 1)	*0103	*0601	*1502
	HLA-A	HLA-B	DRB1
A3-Cw7-B7-DR15(2)	*0301	*0702	*1501
A1-B51-DR15(2)	*0101	*5101	*1502

HLA-DR15 is genetically linked to HLA-DR51 and HLA-DQ6 (HLA-DQ1) serotypes.

References

^ derived from IMGT/HLA
^ Phelps R, Jones V, Turner A, Rees A (2000). "Properties of HLA class II molecules divergently associated with Goodpasture's disease". Int Immunol. 12 (8): 1135–43. doi:10.1093/intimm/12.8.1135. PMID 10917888.
^ Masterman T, Ligers A, Olsson T, Andersson M, Olerup O, Hillert J (2000). "HLA-DR15 is associated with lower age at onset in multiple sclerosis". Annals of Neurology. 48 (2): 211–9. doi:10.1002/1531-8249(200008)48:2<211::AID-ANA11>3.0.CO;2-R. PMID 10939572. S2CID 9624250.
^ Ungar B, Mathews J, Tait B, Cowling D (1981). "HLA-DR patterns in pernicious anaemia". Br Med J (Clin Res Ed). 282 (6266): 768–70. doi:10.1136/bmj.282.6266.768. PMC 1504598. PMID 6783164.
^ Bilir M, Sipahi S, Yilmaz E, et al. (2007). "Analysis of HLA antigens in Turkish sarcoidosis patients". South. Med. J. 100 (4): 356–9. doi:10.1097/SMJ.0b013e31802f3763. PMID 17458393. S2CID 37606199.
^ Hong SC, Lin L, Lo B, et al. (January 2007). "DQB1*0301 and DQB1*0601 modulate narcolepsy susceptibility in Koreans". Hum. Immunol. 68 (1): 59–68. doi:10.1016/j.humimm.2006.10.006. PMID 17207713.
^ Peled N, Amar A, Peled E, Brautbar C, Pillar G (2002). "DRB1*1502-DQB1*0601-DQA1*0103 and DRB1*04-DQB1*0302 in Jewish hypersomnolent patients". Sleep Med. 3 (3): 267–70. doi:10.1016/S1389-9457(01)00155-1. PMID 14592217.
^ Douroudis K, Tarassi K, Athanassiades T, et al. (2007). "HLA alleles as predisposal factors for postmenopausal osteoporosis in a Greek population". Tissue Antigens. 69 (6): 592–6. doi:10.1111/j.1399-0039.2007.00833.x. PMID 17498269.
^ Robertson J, Wu J, Arends J, Glass W, Southwood S, Sette A, Lou Y (2005). "Characterization of the T-cell epitope that causes anti-GBM glomerulonephritis". Kidney Int. 68 (3): 1061–70. doi:10.1111/j.1523-1755.2005.00498.x. PMID 16105036.
^ Phelps R, Rees A (1999). "The HLA complex in Goodpasture's disease: a model for analyzing susceptibility to autoimmunity". Kidney Int. 56 (5): 1638–53. doi:10.1046/j.1523-1755.1999.00720.x. PMID 10571772.
^ Garavito G, Yunis E, Egea E, Ramirez L, Malagón C, Iglesias A, De La Cruz O, Uribe O, Navarro E, Martinez P, Jaraquemada D (2004). "HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos". Hum Immunol. 65 (4): 359–65. doi:10.1016/j.humimm.2004.01.016. PMID 15120191.
^ ^a ^b Slavin R, Hutcheson P, Chauhan B, Bellone C (2004). "An overview of allergic bronchopulmonary aspergillosis with some new insights". Allergy Asthma Proc. 25 (6): 395–9. PMID 15709450.
^ ^a ^b Quelvennec E, Bera O, Cabre P, Alizadeh M, Smadja D, Judge F, Edan G, Semana G (2003). "Genetic and functional studies in multiple sclerosis patients from Martinique attest for a specific and direct role of the HLA-DR locus in the syndrome". Tissue Antigens. 61 (2): 166–71. doi:10.1046/j.0001-2815.2002.00008.x. PMID 12694585.
^ Takeuchi F, Nakano K, Nabeta H, Hong G, Kawasugi K, Mori M, Okudaira H, Kuwata S, Tanimoto K (2005). "Genetic contribution of the tumour necrosis factor (TNF) B + 252*2/2 genotype, but not the TNFa,b microsatellite alleles, to systemic lupus erythematosus in Japanese patients". International Journal of Immunogenetics. 32 (3): 173–8. doi:10.1111/j.1744-313X.2005.00504.x. PMID 15932622. S2CID 10012283.
^ Apple R, Erlich H, Klitz W, Manos M, Becker T, Wheeler C (1994). "HLA DR-DQ associations with cervical carcinoma show papillomavirus-type specificity". Nat Genet. 6 (2): 157–62. doi:10.1038/ng0294-157. PMID 8162070. S2CID 24141516.
^ Manoussakis M, Georgopoulou C, Zintzaras E, Spyropoulou M, Stavropoulou A, Skopouli F, Moutsopoulos H (2004). "Sjögren's syndrome associated with systemic lupus erythematosus: clinical and laboratory profiles and comparison with primary Sjögren's syndrome". Arthritis Rheum. 50 (3): 882–91. doi:10.1002/art.20093. PMID 15022331.
^ Petrushkin, Harry; Thomas, Dhanes; Vaughan, Robert; Kondeatis, Elli; Stanford, Miles R.; Edelsten, Clive; Wallace, Graham R. (2015-04-01). "Possession of the HLA-DRB1*1501 Allele and Visual Outcome in Idiopathic Intermediate Uveitis". JAMA Ophthalmology. 133 (4): 482–483. doi:10.1001/jamaophthalmol.2014.5868. ISSN 2168-6165. PMID 25634309.
^ ^a ^b Sirikong M, Tsuchiya N, Chandanayingyong D, Bejrachandra S, Suthipinittharm P, Luangtrakool K, Srinak D, Thongpradit R, Siriboonrit U, Tokunaga K (2002). "Association of HLA-DRB1*1502-DQB1*0501 haplotype with susceptibility to systemic lupus erythematosus in Thais". Tissue Antigens. 59 (2): 113–7. doi:10.1034/j.1399-0039.2002.590206.x. PMID 12028537.
^ Kuwana M, Kaburaki J, Arnett F, Howard R, Medsger T, Wright T (1999). "Influence of ethnic background on clinical and serologic features in patients with systemic sclerosis and anti-DNA topoisomerase I antibody". Arthritis Rheum. 42 (3): 465–74. doi:10.1002/1529-0131(199904)42:3<465::AID-ANR11>3.0.CO;2-Y. PMID 10088769.
^ García Borrás S, Diez C, Cotorruelo C, Pellizon O, Biondi C, Beloscar J, Bottasso O, Racca A (2006). "HLA class II DRB1 polymorphism in Argentinians undergoing chronic Trypanosoma cruzi infection". Ann Clin Biochem. 43 (Pt 3): 214–6. doi:10.1258/000456306776865205. PMID 16704757. S2CID 41178678.
^ ^a ^b Maciag P, Schlecht N, Souza P, Franco E, Villa L, Petzl-Erler M (2000). "Major histocompatibility complex class II polymorphisms and risk of cervical cancer and human papillomavirus infection in Brazilian women". Cancer Epidemiol Biomarkers Prev. 9 (11): 1183–91. PMID 11097225.