HLA-DOB

HLA-DOB
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesHLA-DOB, DOB, major histocompatibility complex, class II, DO beta, HLA_DOB
External IDsOMIM: 600629; MGI: 95925; HomoloGene: 1602; GeneCards: HLA-DOB; OMA:HLA-DOB - orthologs
Orthologs
SpeciesHumanMouse
Entrez

3112

15002

Ensembl

ENSMUSG00000041538

UniProt

P13765

n/a

RefSeq (mRNA)

NM_002120

NM_010389

RefSeq (protein)

NP_002111

n/a

Location (UCSC)Chr 6: 32.81 – 32.82 MbChr 17: 34.46 – 34.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

HLA class II histocompatibility antigen, DO beta chain is a protein that in humans is encoded by the HLA-DOB gene.[5]

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.[5]

References

  1. ^ a b c ENSG00000241910, ENSG00000243612, ENSG00000239457, ENSG00000241386, ENSG00000241106 GRCh38: Ensembl release 89: ENSG00000243496, ENSG00000241910, ENSG00000243612, ENSG00000239457, ENSG00000241386, ENSG00000241106 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041538 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: HLA-DOB major histocompatibility complex, class II, DO beta".

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