HLA-A29

HLA-A29
(MHC Class I, A cell surface antigen)
HLA-A29
About
Proteintransmembrane receptor/ligand
Structureαβ heterodimer
SubunitsHLA-A*29--, β2-microglobulin
Older namesA19
Subtypes
Subtype
allele
Available structures
A29.1 *2901
A29.2 *2902
{{{cNick3}}} *29{{{cAllele3}}}
{{{cNick4}}} *29{{{cAllele4}}}
Alleles link-out to IMGT/HLA database at EBI

HLA-A29 (A29) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α29 subset of HLA-A α-chains. For A29, the alpha "A" chain are encoded by the HLA-A*29 allele group and the β-chain are encoded by B2M locus.[1] This group currently is dominated by A*2902. A29 and A*29 are almost synonymous in meaning. A29 is a split antigen of the broad antigen serotype A19. A29 is a sister serotype of A30, A31, A32, A33, and A74.

Further information: History and naming of human leukocyte antigens

A29 is more common in Western Africa and Southwestern Europe.

Serotype

A29 recognition of some HLA A*29 gene products[2]
A*29 A29 Sample
allele % size (N)
*2901 96  119
*2902 99 1148


Allele distribution

HLA A*2902 frequencies
Study populationFreq.
 (in %)[3]
Spain Pas Valley13.5
Spain Basque Gipuzkoa Pro…12.5
South Africa Tswana12.2
South African Natal Zulu11.0
Cameroon Yaounde10.4
Cameroon Pygmy Baka10.0
Zimbabwe Harare Shona9.6
Burkina Faso Fulani9.5
Spain Catalonia Girona9.3
Spain Ibizans9.3
Tunisia Ghannouch9.1
Saudi Arabia8.7
Cameroon Bamileke8.4
Cameroon Bakola Pygmy8.3
Spain Murcia8.3
Spain Menorca8.2
Spain Basque Arratia Vall…8.0
Cameroon Sawa7.7
Spain North Cabuernigo7.7
Tunisia7.2
Portugal Centre7.0
Spain Eastern Andalusia6.9
Tunisia6.7
Cameroon Beti6.3
France Corsica6.0
Scotland Orkney6.0
Spain North Cantabrian6.0
Zambia Lusaka5.8
Kenya Luo5.3
England Liverpool5.2
France South East5.1
Ireland Northern4.9
Kenya4.9
Tunisia Tunis4.9
USA Hispanic4.9
Kenya Nandi4.8
Mongolia Hoton4.8
Mongolia Khoton Tarialan4.8
England Manchester4.8
England Newcastle4.7
Pakistan Karachi Parsi4.4
USA Caucasian (2)4.3
Morocco 'berber' Nador Me…4.1
Israeli Jews3.9
England Lancaster3.8
India Jalpaiguri Toto3.8
Senegal Niokholo Mandenka3.8
Belgium3.7
Italy3.6
Wales3.6
Morocco3.4
Mali Bandiagara3.3
Ireland South3.2
Uganda Kampala3.1
Australia New South Wales3.0
Brazil3.0
Macedonia (4)3.0
China Yunnan Han (2)2.9
Greece (3)2.9
India North Delhi2.7
Peru Arequipa2.7
Taiwan Hakka2.7
USA North American Native…2.7
Italy South Campania2.6
Italy Bergamo2.6
Algeria12.5
India Kerala Hindu Nair2.4
Israel Gaza Palestinians2.4
Mexico Mestizos2.4
Guatemala Mayans2.3
German Essen2.0
India West Coast Parsis2.0
Israel Arab Druse2.0
Romanian1.9
Sudanese1.8
Pakistan Brahui1.7
Thailand Northeast1.6
China Harbin Man1.5
Guinea Bissau1.5
Italy Sardinia pop31.5
Mexico Sonora Seri1.5
Pakistan Pathan1.5
Turkey1.3
Czech Republic1.4
Sweden Stockholm1.4
Oman1.3
Sweden Uppsala County1.2
Russia Nenets1.2
Allele frequencies presented, only
HLA A*2901 frequencies
Study populationFreq.
 (in %)[3]
Georgia Tbilisi Kurds6.7
Mexico Guadalajara Mestiz…6.3
CAR Mbenzele Pygmy5.7
Israel Arab Druse4.5
Pakistan Karachi Parsi4.4
Iran Baloch2.8
Taiwan Hakka2.7
Kenya2.1
Saudi Arabia Guraiat and …2.1
India West Coast Parsis2.0
India North Hindus1.9
Jordan Amman1.7
Pakistan Brahui1.7
China Guangzhou1.5
India New Delhi1.5
Pakistan Pathan1.5
Singapore Thai1.5
South African Natal Zulu1.5
Georgia Svaneti Svans1.3
Kenya Nandi1.3
USA Asian1.3
China South Han1.2
Finland1.1
India North Delhi1.1
Kenya Luo1.1
China Inner Mongolia1.0
Portugal Centre1.0
South Korea (3)1.0
Pakistan Baloch0.8
Croatia0.7
Thailand0.7
Ireland South0.6
Romanian0.6
Uganda Kampala0.6
USA San Antonio Caucasian…0.6
Allele frequencies presented, only

Haplotypes

For A29-Cw*16-B44 (A*2902:Cw*1601:B*4403) haplotype see Cw*16

References

  1. ^ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
  2. ^ Allele Query Form IMGT/HLA - European Bioinformatics Institute
  3. ^ a b Middleton, D.; Menchaca, L.; Rood, H.; Komerofsky, R. (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–407. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.