HIST1H2AI

H2AC13
Identifiers
Aliases	H2AC13, H2A/c, H2AFC, histone cluster 1, H2ai, histone cluster 1 H2A family member i, H2A clustered histone 13, HIST1H2AI, H2AC11, H2AC15, H2AC17, H2AC16
External IDs	OMIM: 602787; GeneCards: H2AC13
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4QYL, 5KGF
Gene location (Human)
Chr.	Chromosome 6 (human)
End	27,808,667 bp
RNA expression pattern
	Top expressed in
	bone marrow cell; ; gonad; ; monocyte; ; epithelium of colon; ; blood; ; mucosa of transverse colon; ; tonsil; ; rectum; ; thymus; ; ventricular zone;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	enzyme binding; DNA binding; protein binding; protein heterodimerization activity;
Cellular component	nucleosome; extracellular exosome; nucleus; chromosome;
Biological process	chromatin organization; biological process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	8329
	n/a
	ENSG00000196747
	n/a
	P0C0S8
	n/a
	NM_003509
	n/a
	NP_066408; NP_003505
	n/a
	Wikidata
View/Edit Human

Histone H2A type 1 is a protein that in humans is encoded by the HIST1H2AI gene.^[3]^[4]^[5]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196747 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet. 101 (3): 284–94. doi:10.1007/s004390050630. PMID 9439656. S2CID 38539096.
^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
^ ^a ^b "Entrez Gene: HIST1H2AI histone cluster 1, H2ai".