Green AR, Oscier D, et al. (June 2008). "Novel exon 12 mutations in the HIF2A gene associated with erythrocytosis". Blood. 111 (11): 5400–2. doi:10...

activation of HIF2A. However, in tumors the balance of HIF1A and HIF2A is tipped towards HIF2A. While HIF1A serves as a pro-apoptotic factor, HIF2A interacts...

McMullin MF, Lee FS (January 2008). "A gain-of-function mutation in the HIF2A gene in familial erythrocytosis". The New England Journal of Medicine. 358...

patients have somatic gain of function mutations in the genes encoding for HIF2A, leading to prolonged HIF-2α activity and, thus, an increase in its half-life...

susceptibility genes: Pacak–Zhuang Syndrome Hypoxia-inducible factor 2 alpha (HIF2A) Polycythemia Duodenal somatostatinoma Retinal and choroidal vascular changes...

Familial erythrocytosis arising from a gain-of-function mutation in the HIF2A gene of the oxygen sensing pathway. Ulster Medical Journal 77(2). 86-88...

endothelial PAS domain protein 1 Identifiers Symbol EPAS1 Alt. symbols HIF2A, MOP2, PASD2, HLF NCBI gene 2034 HGNC 3374 OMIM 603349 RefSeq NM_001430 UniProt...

c-MET, a proto-oncogene mutated in Hereditary papillary renal carcinoma; HIF2A (EPAS1), which causes a tumor-predisposition syndrome now known as Pacak–Zhuang...

complex pVHL binds and targets several known factors, including HIF1a and HIF2a for ubiquitination. Mechanism of HIF1a activation by hypoxia and role of...