Guillermo Diaz may refer to:

• Guillermo Díaz-Plaja (1909–1984), Spanish literary critic, historian and poet.
• Guillermo Díaz (footballer, born 1926), Chilean footballer
• Guillermo Díaz (footballer, born 1930) (1930–1997), Chilean footballer
• Guillermo Díaz Gea (born 1944), Mexican politician
• Guillermo Díaz (wrestler) (born 1964), Mexican Olympic wrestler
• Guillermo Díaz (actor) (born 1975), American actor
• Guillermo Díaz (footballer, born 1979), Uruguayan footballer
• Guillermo Diaz (basketball) (born 1985), Puerto Rican basketball player
• Guillermo Díaz (footballer, born 1994), Chilean footballer
• Memo Diaz, (born 1995), American soccer player

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