Of the several plausible ways Black has to defend his e-pawn, 2...Qf6 is considered one of the weaker choices, since the queen is developed prematurely and can become a target for attack. Also, the black knight on g8 is deprived of its most natural square. There is, however, no obvious refutation of this opening; White's advantage consists mainly of smoother development.
Although it is a popular opening choice by novice players, it has also been used by players who, according to International MasterGary Lane, "should know better".
Examples
Greco line
Greco himself illustrated the following amusing line against this defence in 1620: