Gmina Domaszowice is a rural gmina (administrative district) in Namysłów County, Opole Voivodeship, in south-western Poland. Its seat is the village of Domaszowice, which lies approximately 14 kilometres (9 mi) east of Namysłów and 43 km (27 mi) north of the regional capital Opole.
The gmina covers an area of 113.86 square kilometres (44.0 sq mi), and as of 2019 its total population is 3,591.