Gmina Chrzypsko Wielkie is a rural gmina (administrative district) in Międzychód County, Greater Poland Voivodeship, in west-central Poland. Its seat is the village of Chrzypsko Wielkie, which lies approximately 24 kilometres (15 mi) east of Międzychód and 54 km (34 mi) north-west of the regional capital Poznań.
The gmina covers an area of 84.33 square kilometres (32.6 sq mi), and as of 2006 its total population is 3,293.