His major contributions are in the field of practical numbers. This prime-like sequence of numbers is known for having an asymptotic behavior and other distribution properties similar to the sequence of primes. Melfi proved two conjectures both raised in 1984[2] one of which is the corresponding of the Goldbach conjecture for practical numbers: every even number is a sum of two practical numbers. He also proved that there exist infinitely many triples of practical numbers of the form .
Another notable contribution has been in an application of the theory of modular forms, where he found new Ramanujan-type identities for the sum-of-divisor functions. His seven new identities extended the ten other identities found by Ramanujan in 1913.[3] In particular he found the remarkable identity
where is the sum of the divisors of and is the sum of the third powers of the divisors of .
Among other problems in elementary number theory, he is the author of a theorem that allowed him to get a 5328-digit number that has been for a while the largest known primitive weird number.