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Albani was born in Rome, the son of Carlo Albani, Duke of Soriano; his grand-uncle was Pope Clement XI (Gianfrancesco Albani). Furthermore, two of his uncles Annibale Albani and Alessandro Albani were cardinals, and was himself uncle of cardinal Giuseppe Albani (with whom he was, for two years, concurrently cardinal).
In October 1740 he was made Protonotary apostolic, quickly followed by being made the vicar of the patriarchal Basilica di Santa Maria Maggiore in March 1742. Later in the same year, in November, he was made president of the Papal chamber; and also cleric of the Apostolic Chamber less than a year later (September 1743). He further became relator of the S. C. of Indulgences and Sacred Relics in 1743.
His political orientation appeared to be pro-Austrian, anti-French and, with the French invasion of the Papal States in 1798 he absconded to Naples, before moving to Venice where the Papal conclave of 1800 took place. He died in Rome on the 15 September 1803—his funeral was held in the church of Santa Maria in Vallicella, Rome and was buried in the patriarchal Liberian basilica.