Novack attended Harvard University for five years, though without earning a degree, and was on a successful track in the publishing business when the beginning of the Great Depression radicalized him. He joined the Trotskyist movement (Communist League of America) in 1933, along with his first wife Elinor Rice, and was an elected member of the National Committee of the Socialist Workers Party (SWP) from 1940 to 1973.
In 1937-40, Novack served as the secretary of the American Committee for the Defence of Leon Trotsky. This body initiated the celebrated 1937 Dewey Commission that inquired into the charges made against Trotsky in the Moscow show trials, and found them to have been a complete frame-up. He played a major role in the defense campaign for the 18 SWP leaders imprisoned in World War II under the Smith Act.
Novack remained a member of the SWP until his death, although he withdrew from regular political activity after the death of his second wife, Evelyn Reed, in 1979, living quietly in a New York senior citizens' home.
Novack, George (1942), Introduction to the Logic Of Marxism, New York: Pathfinder Press
Novack, George (1965), The Origins of Materialism, New York: Pathfinder Press
Novack, George (1969), Empiricism and its Evolution: A Marxist View, New York: Pathfinder Press
Novack, George (1969), Revolutionary Dynamics of Women's Liberation, New York: Pathfinder Press
Novack, George (1970), Genocide Against the Indians, New York: Pathfinder Press
Novack, George (1971), Democracy and Revolution, New York: Pathfinder Press
Novack, George (1972), Understanding History: Marxist Essays, New York: Pathfinder Press
Novack, George (1973), Humanism and Socialism, New York: Pathfinder Press
Novack, George and Mandel, Ernest (1973), The Marxist Theory of Alienation, 2nd ed., New York: Pathfinder Press{{citation}}: CS1 maint: multiple names: authors list (link)
Novack, George (1975), Pragmatism versus Marxism: An appraisal of John Dewey's philosophy, New York: Pathfinder Press
Novack, George (1976), America's Revolutionary Heritage, New York: Pathfinder Press
Novack, George (1978), Polemics in Marxist Philosophy, New York: Pathfinder Press
Novack, George. Radical Intellectuals in the 1930s. International Socialist Review Vol. 29, No. 2, March–April 1968, pp. 21–34. Text of speech to Socialist Scholars Conference, N. Y., Sept. 1967. Transcription/Editing: 2005 by Daniel Gaido. HTML Markup: 2005 by David Walters. Retrieved May 13, 2005.