Williams' 1957 paper Pleiotropy, Natural Selection, and the Evolution of Senescence is one of the most influential in 20th century evolutionary biology, and contains at least 3 foundational ideas.[4] The central hypothesis of antagonistic pleiotropy remains the prevailing evolutionary explanation of senescence. In this paper Williams was also the first to propose that senescence should be generally synchronized by natural selection. According to this original formulation
... if the adverse genic effects appeared earlier in one system than any other, they would be removed by selection from that system more readily than from any other. In other words, natural selection will always be in greatest opposition to the decline of the most senescence-prone system.
This important concept of synchrony of senescence was taken up a short time later by John Maynard Smith, and the origin of the idea is often misattributed to him, including in his obituary in the journal Nature.[5] Finally, Williams' 1957 paper was the first to outline the "grandmother hypothesis". William's formulation stated that natural selection might select for menopause and post-reproductive life in females (though not explicitly mentioning grandchildren or the inclusive fitness contribution of grand-parenting).
In his first book, Adaptation and Natural Selection (1966), Williams advocated a "ground rule - or perhaps doctrine would be a better term - ... that adaptation is a special and onerous concept that should only be used where it is really necessary",[6] and that, when it is necessary, selection among genes or individuals would in general be the preferable explanation for it. He elaborated this view in later books and papers, which contributed to the development of a gene-centered view of evolution. Richard Dawkins built upon Williams' ideas around selection and genes in his book The Selfish Gene (1976).[7]
In Sex and Evolution (1975), he attempted to explain why many species use exclusive sexual reproduction despite its “twofold cost". He proposed several explanatory models ( “aphid-rotifer model,” the “strawberry-coral model,” and “elm-oyster model"), though found all of them insufficient.[8] He even considered the possibility that sex is a maladaption for some species:
When major taxonomic groups all share a certain feature, it is unlikely that the feature has the same adaptive significance throughout the group. It may even be maladaptive for the majority... The fact that parthenogenesis or its equivalent, if found in a vertebrate population, has always replaced sexual reproduction entirely, is decisive evidence of the maladaptive nature of sexuality in these organisms. (Chapter 9)
In later books, including Natural Selection: Domains, Levels and Challenges, Williams softened his views on group selection, recognizing that clade selection, trait group selection and multilevel selection did sometimes occur in nature, something he had earlier thought to be so unlikely it could be safely ignored.[9][10]
Williams became convinced that the genic neo-Darwinism of his earlier years, while essentially correct as a theory of microevolutionary change, could not account for evolutionary phenomena over longer time scales, and was thus an "utterly inadequate account of the evolution of the Earth's biota" (1992, p. 31). In particular, he became a staunch advocate of clade selection – a generalisation of species selection to monophyletic clades of any rank – which could potentially explain phenomena such as adaptive radiations, long-term phylogenetic trends, and biases in rates of speciation/extinction. In Natural Selection (1992), Williams argued that these phenomena cannot be explained by selectively-driven allele substitutions within populations, the evolutionary mechanism he had originally championed over all others. This book thus represents a substantial departure from the position of Adaptation and Natural Selection.[11]
Williams, G.C., ed. 1971. Group Selection. Aldine-Atherton, Chicago.
Williams, G.C. 1975. Sex and Evolution. Princeton University Press, Princeton, N.J.
Paradis, J. and G.C. Williams. 1989. T.H. Huxley's Evolution and Ethics : with New Essays on its Victorian and Sociobiological Context. Princeton University Press, Princeton, N.J.
Williams, G.C. 1992. Natural Selection: Domains, Levels, and Challenges. Oxford University Press, New York.
Nesse, R.M. and G.C. Williams. 1994. Why We Get Sick : the New Science of Darwinian Medicine. Times Books, New York.
Williams, G.C. 1996. Plan and Purpose in Nature. Weidenfeld & Nicolson, London (published in the U.S. in 1997 as The Pony Fish's Glow : and Other Clues to Plan and Purpose in Nature. Basic Books, New York).
Selected papers
Williams, G. C. (1957). "Pleiotropy, natural selection, and the evolution of senescence". Evolution. 11 (4): 398–411. doi:10.2307/2406060. JSTOR2406060.
Williams, G. C.; Williams, D. C. (1957). "Natural selection of individually harmful social adaptations among sibs with special reference to social insects". Evolution. 11 (1): 32–39. doi:10.2307/2405809. JSTOR2405809.
Williams, G. C. (1966). "Natural selection, the costs of reproduction, and a refinement of Lack's principle". The American Naturalist. 100 (916): 687–690. doi:10.1086/282461. JSTOR2459305. S2CID84993886.
Hrdy, S. B.; Williams, G. C. (1983). "Behavioral biology and double standard". In Wasser, S. K. (ed.). Social Behavior of Female Vertebrates. New York, United States: Academic Press. pp. 3–17. ISBN9780124313415.
Taylor, P. O.; Williams, G. C. (1984). "Demographic parameters at evolutionary equilibrium". Canadian Journal of Zoology. 62 (11): 2264–2271. doi:10.1139/z84-329.
Williams, G. C. (1985). "A defense of reductionism in evolutionary biology". In Dawkins, R.; Ridley, M. (eds.). Oxford Surveys in Evolutionary Biology: Volume 2. Oxford, United Kingdom: Oxford University Press. pp. 1–27. ISBN9780198541745.
Williams, G. C. (1988). "Huxley's Evolution and Ethics in Sociobiological Perspective". Zygon. 23 (4): 383–438. doi:10.1111/j.1467-9744.1988.tb00852.x.
Williams, G. C. (1992). "Gaia, nature worship and biocentric fallacies". The Quarterly Review of Biology. 67 (4): 479–486. doi:10.1086/417796. JSTOR2832018. S2CID84360055.
Williams, G. C. (2008). "A package of information". In Brockman, J. (ed.). The Third Culture: Beyond The Scientific Revolution. New York, United States: Touchstone. pp. 38–50. ISBN9780684823447.
Williams supervised an undergraduate project in 1985 which consisted of a student, Mitchell Behm, tossing live animals into tubs with domesticated ferrets, which Behm subsequently admitted he partly did "for his own amusement." Dr. Charles Middleton, Director of the Division of Laboratory Animal Resources stated, "If animals are just going to tear each other up, the experiment would not have been approved." Ferrets were illegal in New York at the time, without a license, which neither individual had.
After police investigation, Williams received a formal reprimand from SUNY Stony Brook for never receiving approval because of not detailing the pain of the animals involved, and for allowing non-campus animals to participate. Because the statute of limitations had expired, Williams narrowly escaped strict disciplinary action, in addition to criminal prosecution. Dr. Mark Lerman, Medical Director of Lifeline for Wildlife said there was no justification and that the experiment was completely useless.[14]
^Williams, George C. (1957). "Pleiotropy, Natural Selection, and the Evolution of Senescence". Evolution. 11 (4): 398–411. doi:10.2307/2406060. JSTOR2406060.
