As he was age 89 when the show premiered, George Burns was billed as the oldest person ever to "star" in a television series. Burns had been around television in one way or another since shortly after its inception; like many old-time radio stars he had brought his routine over more-or-less intact from the older medium. However, his actual role in this series was rather slight; aside from lending his name, introducing the night's program, and providing an occasional voice-over narration, Burns was not involved in any of the episodes as an actor and those who tuned in expecting to see him as such were disappointed.
George Burns Comedy Week did poorly in the Nielsen ratings and was last broadcast on Christmas night 1985. It marked Burns' last ongoing role in a television series, although he continued to appear as a guest on programs for the next nine years, until suffering a serious fall at age 98 which ended his active performing career (Burns died at age 100).