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Gary Bassell

Gary J. Bassell
Born
Hartford, CT
Alma mater
Scientific career
Workplaces
ThesisDevelopment and application of ultrastructural in situ hybridization to visualize the spatial organization of mRNA (1992)
Robert H. Singer
Other academic advisors
Kenneth S. Kosik
Websitehttps://med.emory.edu/directory/profile/?u=GBASSEL

Gary J. Bassell is an American cell biologist who is the Charles Howard Candler Professor and Chair of the Department of Cell Biology at Emory University School of Medicine.[1][2] His research focuses on mRNA localization and local protein synthesis within neurons, how these processes are disrupted in neurological disease, and potential therapies.[1][2]

Early life and education

Bassell majored in chemistry at Framingham State University, where he initially considered becoming a high school science teacher and briefly had an interest in forensic science before getting involved in a biochemistry research project.[3] This led him to pursue a PhD in biomedical science at the University of Massachusetts Medical School, which he completed in 1992.[1][3] His thesis research, conducted in the lab of Robert H. Singer,[1][4] focused on the interactions of polyribosomes, mRNA, and RNA-binding proteins with cytoskeletal filaments in fibroblasts.[2][3]

Following his PhD, Bassell became interested in the neuron as a model for studying RNA transport due to its highly polarized nature.[3] He conducted his postdoctoral research with Kenneth Kosik in the Center for Neurological Diseases of the Brigham and Women’s Hospital at Harvard Medical School.[1][2][3][5]

Career

In 1995, Bassell joined the faculty of Albert Einstein College of Medicine, first as a member of the Department of Anatomy and Structural Biology, then, in 1998, as a member of the Department of Neuroscience and Rose F. Kennedy Intellectual and Developmental Disabilities Research Center.[1][2] Bassell moved to Emory University School of Medicine in 2005,[1] where he has been rofessor in the departments of cell biology and neurology since 2009.[2] Bassell currently holds the following positions at Emory: Charles Howard Candler professor of cell biology, chair of Department of Cell Biology,[1] professor of Department of Neurology,[2] and scientific director of the Emory Stem Cell and Organoids Core.[6] Bassell is also a member of the Scientific and Clinical Advisory Committee for the National Fragile X Foundation and a standing member of the National Institute of Health Neurological Science and Disorders Study Section (2023-2027).[7]

Research

The Bassell lab is interested in understanding the roles mRNA-binding proteins play in post-transcriptional regulation of gene expression in the nervous system.[8] This includes investigating mRNA-binding proteins in mRNA transport and local protein synthesis needed for neuronal development and synaptic plasticity.[8] The Bassell lab is also interested in how failures of these processes can lead to neurodevelopmental and neurodegenerative disorders, such as Fragile X Syndrome, autism spectrum disorders, spinal muscular atrophy, amyotrophic lateral sclerosis, and myotonic dystrophy.[8] The lab uses mice to model neurological diseases and investigate the role of mRNA regulation and local protein synthesis in axon guidance, synapse development and neuronal signaling.[8] As director of the Laboratory of Translational Cell Biology (LTCB), Bassell is also interested in the development of models of neurologic diseases using induced pluripotent stem cell (iPSC) derived from patients at Emory University Hospital.[1][2]

Awards and honors

  • 2013 - NARSAD Distinguished Investigator[2][9][10]
  • 2011 - Trailblazer Award, Autism Speaks[2]
  • 2010 - Distinguished Alumni Achievement Award, Framingham State University
  • 2009 - NARSAD Independent Investigator Award[10]
  • 2004 - Irma Hirschl/Weill-Caulier Career Scientist Award[11]
  • 2004 - Dana Foundation Award in Brain Imaging (Molecular and Cellular Imaging)[2]
  • 1996 - Basal O’Connor Scholar Award, March of Dimes[2]

Selected publications

References

  1. ^ a b c d e f g h i "People in the Bassell Lab". Bassell Laboratory. 2025. Retrieved November 29, 2025.
  2. ^ a b c d e f g h i j k l "History: Department History and Departmental Chairs". Emory University School of Medicine: Department of Cell Biology. 2025. Retrieved November 29, 2025.
  3. ^ a b c d e Swanger, Sharon (August 17, 2013) [February 2007]. "PI Personals: Dr. Gary Bassell". The Central Sulcus. Retrieved November 22, 2025.
  4. ^ "Alumni: Former Lab Members". Albert Einstein College of Medicine: Laboratory of Robert H. Singer. Retrieved November 22, 2025.
  5. ^ "People". Kosik Lab. Retrieved November 22, 2025.
  6. ^ "About: Who we are". Emory Stem Cell and Organoids Core. Retrieved November 29, 2025.
  7. ^ "Advisory Committee". National Fragile X Foundation. 2025. Retrieved November 29, 2025.
  8. ^ a b c d "Gary Bassell PhD". Emory University School of Medicine Profile. 2025. Retrieved December 2, 2025.
  9. ^ "Brain & Behavior Research Foundation Awards $1.5 Million in NARSAD Distinguished Investigator Grants". Brain & Behavior Research Foundation. January 14, 2013. Retrieved September 13, 2025.
  10. ^ a b "Foundation Grantee's Since 1987" (PDF). Brain & Behavior Magazine: Pathways to the Future. November 2017. Retrieved September 13, 2025.
  11. ^ "IRMA T. HIRSCHL/MONIQUE WIELL CAULIER CHARITABLE TRUSTS ALBERT EINSTEIN COLLEGE OF MEDICINE AWARD RECIPIENTS" (PDF). December 30, 2019. Retrieved September 13, 2025.

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