The story begins in St. Louis, Missouri, where Gary Newton bids farewell to his nursing home patients as he prepares to embark on a journey following the Lewis and Clark trail. Meanwhile, his friend Mike finds himself in a predicament after being caught in bed with a girl named Julie by her parents. Gary sets off on his trip in his SUV, with Mike unexpectedly joining him to escape Julie's angry father, Officer Dick. Along the way, they encounter a hitchhiker who initially seems helpful but ends up robbing them and stealing their car. After spending a night in the woods and mistakenly eating a little girl's pet rabbit, Gary and Mike are arrested. They explain their ordeal to the police, who eventually verify their story and release them. After being Confronted by an Angry Mob of Evangelicals and Being Rescued by a Group of Satanists, They Find their Wrecked SUV in an Impound Lot. Determined to continue their journey, Gary and Mike use money hidden by Mike to purchase a beat-up 1964 Bel Air. They also buy a replacement rabbit for the girl whose pet they accidentally ate, but tragically, the new rabbit meets a similar fate shortly after. Despite the chaotic events, Gary reflects on the trip with a mix of frustration and camaraderie towards Mike, who remains determined to keep exploring rather than face his father's wrath. The episode ends with Gary and Mike driving aimlessly away from home, continuing their unpredictable adventure.

Featured Music: "Are You Ready For My Love" by Rockell and "Get Off" by The Dandy Warhols

On their way through the Bible-Belt in fictional Wenville, Texas, they stop to get some food. They pull in to a Jesus-themed restaurant, aptly named "Baptist Burger", whereupon Gary and the drive-thru clerk become smitten with each other. In hilarious sit-com fashion, he fails every time to notice that she has a growth that covers half her face, but Mike sure does...until Gary goes to her house to meet her. Meanwhile, Mike tries to win a Hotrod in a "hands on the Hotrod" contest.

Featured Music: "Loose" by Primer 55 and "Eye of the Tiger" by Survivor

The duo now find themselves at a Phish concert in Vermont where Gary accidentally swallows 4 hits of acid. When he comes to his senses, he discovers he's married to a 35-year-old hippie woman (voiced by Shannen Doherty) with three kids. Officer Dick also manages to find the duo's car after tracking them for so long and seeks to exact his revenge on Mike, under the cover as a hippie himself. Meanwhile, Mike discovers the secret evil behind the band's unwarranted success. This episode features a strata-cut animation sequence by David Daniels.

Featured Music: "Voices" by Disturbed and "This's What It Feels Like" by Beachwood Sparks

Gary and Mike go on MTV's Road Rage (a play on Road Rules) and visit Mike's brother, Ben in Santa Fe, New Mexico. Ben gets jealous of Mike because he becomes more popular than him, and Gary meets a new "friend". WWF wrestler Chyna makes a guest appearance and falls in love with Gary's new "friend" at the end of the episode. Officer Dick catches up with Ben, whom he believes is Mike under an assumed identity, and shoots out the tires of his SUV which he won at the end of the Road Rage program.

Featured Music: "Gonna Make You Sweat (Everybody Dance Now)" by C+C Music Factory, "I Think I Love You" by David Cassidy, "It's Now or Never" by Elvis Presley, “Wild Thing" by The Troggs and "Who I Am (Chyna)" by WWE, Jim Johnston

Gary and Mike enter the nation's capital, where they're in desperate need of money...so they hunt down a friend of Mike's mom. Soon, they're working on a campaign for a crusading senator's health care legislation. Gary seems to be helping a great deal, but without knowing it is causing more trouble than the campaign can stand, meanwhile Mike finds himself falling for a much, much older woman who is a Supreme Court Justice.

Featured Music: "Hot" by Black Eyed Peas

It's Viva Las Vegas for Gary and Mike, when Mike forms a plan to help Gary get rid of his "virginitis" by setting an unknowing Gary up with an escort. Gary thinks the girl really likes him and winds up falling for her hard. Meanwhile Mike is counting cards in the casino owned by the same honked-off mobsters who gave them their hotel room, as his source of income.

Featured Music: "Someone Else's Blues" by David Bromberg

Gary and Mike are in The Big Apple, New York, and their car gets stolen; so they decide to disguise themselves as Jews and go to a bar mitzvah. Some other Jewish people chase them down to the subway. Gary and Mike have an argument and separate, and Gary becomes one of the "Mole People" who live in the sewers while Mike seems to luck out at every turn from being handed $50 by a generous blind man, to getting to model with European supermodels, to bedding with them. Presumably after they reunite and reconcile, they would head to Atlantic City, New Jersey, as mentioned. However, this was not made into an episode.

Featured Music: "Baby's Got a New Revelation" by The Exies

In fictional rural Baylor, Minnesota, as Hasselhoff's comet nears, Gary and Mike meet up with two girls whom turn out to be part of a cult. Gary wants to get out of there quick, but Mike says he's too close to getting some to leave, so Gary reluctantly agrees to stay the night. Soon, Gary is pulled into the cult with his new name: Ga. Hence, it's up to Mike, whose cult name is Huh, to save Gary in time.

While making their way to Chicago, Illinois, Gary has the inside of his mouth stung by a bee and is rushed to a hospital. After a close call with death, Gary soon decides he should come clean with his father about his road trip with his buddy Mike and breaks the news to him on a special Father's Day episode of "Jerry".

Based on the continuity of this episode, it was likely meant to be placed after "The Virgin Gary".

After traveling from Miami, Florida, to Seattle, Washington, the duo discover Mike's ex-girlfriend, Beth, who has been seen as RazorKat's drummer, is getting married in Miami, prompting Mike to drive all the way back. Mike doesn't like the guy, whom seems to have everything. Thanks to some books about a John Shaft knock-off, Gerald Stroke, Gary is acting emulous in a Shaft-like manner, and helps Mike figure out what Beth's finance is really about, as Mike attempts to sort out his feelings for her. (This episode is said to take place on June 20th, set 3 days after "Springered", which is set on Father's Day. Likely meaning this was intended to be the 5th episode in the series continuity.

In Hollywood, California, the guys attempt to party with the celebrities. They elude an oversexed TV mother and then encounter a strangely compliant person who might be Gwyneth Paltrow.

Featured Music: "Et Meme Que Quai!" by Michel Philippe Gentils, "Crazy" by Patsy Cline and "Out of Control" by The Chemical Brothers

Between Minneapolis and St. Paul, Minnesota, the duo make their way to the Mall of North America (a parody of Mall of America) to spend a large amount of coupons to support themselves for the whole winter...only to discover that the coupons have expired (the coupon book turned out to be sold to Mike by an ex-con who conned Mike into buying it). Through the kindness of a corn dog business owner (played by Stacy Keach), Gary and Mike get a job at Corn Diggity Dog in the Mall. A competitor corn dog company called Porn Dog is putting Corn Diggity Dog out of business until Gary realizes he can save the business by winning a trick Corn Dog competition.

Featured Music: "Hey Song (Rock and Roll Pt. 2)" Hockey Mix by Sports All-Stars

In San Francisco, California Officer Dick finally manages to catch up with the duo again, and pursues them in a high-speed chase. However, like his last two attempts, his efforts would end in vain. After Dick lands into a gay bar, both of them run over a speed-bump, causing Mike to spill his Slurpee on the Marine Corps flag Gary bought for his dad, as well as his shirt. Mike then prompts Gary to take off his shirt and dry it off in the breeze along with the flag. Little do the two of them know that they are driving in front of a Gay Pride Parade on national television which Mr. Newton sees, and mistakenly assumes that Gary is gay and Mike is his partner. After Gary's dad signs him up for the Marines, he goes to a strip club and meets a mysterious stranger, Jared, (voiced by Tim Curry) who tells him he will kill Gary's dad; if Gary kills the stranger's wife. After the wife dies accidentally, Gary must race to save his father's life. However upon stopping Jared, he tells the police Gary killed his wife and then him (after Gary accidentally makes Jared get a lethal injection). They are then chased by the Police themselves and are cornered at an incomplete highway. Gary in turn, feeling trapped by his dad with nowhere to go but down, then tells Mike to make the suicidal jump. The episode ends with a fade to white with the caption "To Be Continued..."   According to co-creator Adam Small, the duo was scripted to survive by landing in the water or something else. 10 more episodes were planned and fully developed for a second season but never saw production on account of the circumstances surrounding the show's cancellation.^{[citation needed]}

Featured Music: "I Will Survive" by Gloria Gaynor