Don Calogero Bertuccione, a boss of the Italian American mafia, through his right arm Don Cefalù, orders the young mafioso Salvatore Lo Coco, a Sicilian emigrated to the US, to return to his hometown Castropizzi to kill Don Nicola Manzano called "Nicky" who's suspected of being a spy.
Salvatore does not want to, but must obey to avoid mafia revenge on his family. Once he arrives in Italy he looks for someone who can replace him, but without success. After a series of grotesque events he manages to enter Don Manzano's villa where he then finds out that Don Bertuccione and his men have been killed.