Frits Prinzen

Frits Prinzen

Frits F.W. Prinzen is an expert on cardiac pacing therapies, both for bradycardia and for heart failure (cardiac resynchronisation therapy, CRT).

Early life and education

He was born July 2, 1954, in Hilversum. He earned a master's degree in medical biology from Utrecht University in 1978, and a PhD in physiology from Maastricht University in 1982.[1]

Career

Prinzen works on cardiac pacing therapies, both for bradycardia and for heart failure (cardiac resynchronisation therapy, CRT). His main research topic is cardiac mechanics and long-term structural and functional adaptations to various conditions, with emphasis on asynchronous electrical activation and cardiac resynchronisation.[2]

In 1995, he took a sabbatical year during which he worked at the Johns Hopkins University in Baltimore, MD, USA, where he dove into the world of MRI tagging of the heart. This work was published in a well-cited article in the Journal of the American College of Cardiology.[3]

Societal impact

His work led to improved cardiological treatments, especially in the field of cardiac pacing. Together with cardiologists and industrial partners he improved and developed pacemakers, pacing wires, and implantation methods.[4] An example is published in NEJM in 2007,[5] describing the case of a child with heart failure who directly benefited by changing the site of the pacemaker wire. This theory was later confirmed in a large clinical trial, published in 2013 in Circulation.[6] In his lab of it was shown for the first time that pacing the left side of the interventricular septum maintained cardiac function.[7][8] This pacing strategy has been adopted in clinical practice.[9] Frits was awarded the CARIM commitment award in 2016.[10]

Published work

Frits Prinzen is co-author of over 280 scientific articles, with over 16,000 citations and an all time H-index of 70.[11]

He contributed to Clinical Cardiac Pacing, Defibrillation and Resynchronization Therapy.[12]

References

  1. ^ "Frits Prinzen | Radcliffe Cardiology". www.radcliffecardiology.com. Retrieved 2022-06-09.
  2. ^ Eindhoven, 3w Media. "Frits Prinzen". Carim Maastricht. Retrieved 2020-10-23.{{cite web}}: CS1 maint: numeric names: authors list (link)
  3. ^ Prinzen, Frits W.; Hunter, William C.; Wyman, Bradley T.; McVeigh, Elliot R. (1999-05-01). "Mapping of regional myocardial strain and work during ventricular pacing: experimental study using magnetic resonance imaging tagging". Journal of the American College of Cardiology. 33 (6): 1735–1742. doi:10.1016/S0735-1097(99)00068-6. ISSN 0735-1097. PMC 2041911. PMID 10334450.
  4. ^ "European Perspectives". Circulation. 126 (18): f103–f108. 2012-10-30. doi:10.1161/CIR.0b013e31827854cd.
  5. ^ Vanagt, Ward Y.; Prinzen, Frits W.; Delhaas, Tammo (2007-12-20). "Reversal of Pacing-Induced Heart Failure by Left Ventricular Apical Pacing". New England Journal of Medicine. 357 (25): 2637–2638. doi:10.1056/NEJMc072317. ISSN 0028-4793. PMID 18094389.
  6. ^ Janoušek Jan; van Geldorp Irene E.; Krupičková Sylvia; Rosenthal Eric; Nugent Kelly; Tomaske Maren; Früh Andreas; Elders Jan; Hiippala Anita; Kerst Gunter; Gebauer Roman A. (2013-02-05). "Permanent Cardiac Pacing in Children: Choosing the Optimal Pacing Site". Circulation. 127 (5): 613–623. doi:10.1161/CIRCULATIONAHA.112.115428. PMID 23275383.
  7. ^ Mills, Robert W.; Cornelussen, Richard N.; Mulligan, Lawrence J.; Strik, Marc; Rademakers, Leonard M.; Skadsberg, Nicholas D.; van Hunnik, Arne; Kuiper, Marion; Lampert, Anniek; Delhaas, Tammo; Prinzen, Frits W. (October 2009). "Left ventricular septal and left ventricular apical pacing chronically maintain cardiac contractile coordination, pump function and efficiency". Circulation: Arrhythmia and Electrophysiology. 2 (5): 571–579. doi:10.1161/CIRCEP.109.882910. ISSN 1941-3084. PMID 19843926.
  8. ^ Mafi-Rad, Masih; Luermans, Justin G. L. M.; Blaauw, Yuri; Janssen, Michel; Crijns, Harry J.; Prinzen, Frits W.; Vernooy, Kevin (March 2016). "Feasibility and Acute Hemodynamic Effect of Left Ventricular Septal Pacing by Transvenous Approach Through the Interventricular Septum". Circulation: Arrhythmia and Electrophysiology. 9 (3): e003344. doi:10.1161/CIRCEP.115.003344. ISSN 1941-3084. PMID 26888445.
  9. ^ Vijayaraman, Pugazhendhi; Subzposh, Faiz A.; Naperkowski, Angela; Panikkath, Ragesh; John, Kaitlyn; Mascarenhas, Vernon; Bauch, Terry D.; Huang, Weijian (December 2019). "Prospective evaluation of feasibility and electrophysiologic and echocardiographic characteristics of left bundle branch area pacing". Heart Rhythm. 16 (12): 1774–1782. doi:10.1016/j.hrthm.2019.05.011. ISSN 1556-3871. PMID 31136869.
  10. ^ Eindhoven, 3w Media. "Home". Carim Maastricht. Retrieved 2020-10-21.{{cite web}}: CS1 maint: numeric names: authors list (link)
  11. ^ "Frits Prinzen".
  12. ^ Ellenbogen, Kenneth A.; Wilkoff, Bruce L.; Auricchio, Angelo; Neal Kay, G.; Lau, Chu-Pak (13 May 2016). Clinical Cardiac Pacing, Defibrillation and Resynchronization Therapy | ScienceDirect. Elsevier. ISBN 9780323378048.