Drandua was born in Uleppi, in present-day Ma'di-okollo District, in the West Nile sub-region, in the Northern Region of Uganda, on 12 August 1943. He was ordained priest on 9 August 1970. He served as priest of the Roman Catholic Diocese of Arua until 27 May 1986.[1]
Bishop Frederick Drandua resigned as Bishop of Arua on 19 August 2009,[1] due to poor health.[2] He died on 1 September 2016, at St. Francis Hospital Nsambya, in Nsambya, Kampala, Uganda, at the age of 73 years.[1][2][3]