He met Edward L. Doheny on a weekend yachting trip in 1919, who hired him to work for his oil enterprise.[2] He became General Counsel and Managing General Agent for Doheny's operations in Mexico from 1921 to 1927, and convinced the Mexican government to hire him for an ambitious road paving project.[2]
He later founded the Hydril Company, a producer of oil drilling equipment.[2] He and his wife, Blanche, were a major contributor to Pomona,[6] where they served as trustees, and where the Seaver Science Center is named after him and several other buildings are named after his family.[7][8] They were also the principal benefactors of the Malibu campus of Pepperdine University, which named its College of Letters, Arts, and Sciences after him,[9][10] and donated portions of their $10.1 million estate (equivalent to $99.2 million in 2023) to other institutions.[11][12]