Buzomi was born in 1576 in Naples then part of the Kingdom of Naples. He was sent to Macau in 1608 and studied theology there for a year. Captain Ferdinand de Costa, after visiting Hội An (known to the Europeans as "Faifo"), told the Jesuit superior in Macau that there was a shortage of priests to minister the Japanese Catholic community and that there were no missionaries for the Vietnamese either.[2] Buzomi then asked for permission to go on a mission in Đàng Trong and was approved.
Buzomi landed in Da Nang on 18 January, 1615. After a time in Hội An and Thanh Chiêm, Buzomi established a mission in Pulocambi in 1618. Commissioned by Nguyễn lordPhúc Lan, Buzomi came back to Macau in 1639; he died there the same year.[3]