The film is part of Star Cinema's 20th anniversary presentation in collaboration with Rebisco on its 50th anniversary. Four Sisters and a Wedding was released in the Philippines on June 26, 2013, and internationally on July 5, 2013.[2]
When CJ, the youngest Salazar sibling, announces his wedding, his sister Gabbie convinces their other sisters to come home as requested by their mother Grace. Teddie, the eldest, is a laid-off teacher now working as a waitress in Madrid. Bobbie, the second sister, is a corporate communications manager in New York living with her boyfriend Tristan and his daughter Trixie. The third sister, Alex, is an assistant film director struggling with her job and her relationship with Bobbie's ex, Chad. Gabbie is a teacher who takes care of their mother. Bobbie faces pressure from Tristan to marry despite having a difficult relationship with Trixie. Teddie, unable to afford a plane ticket, convinces her colleague Frodo to return to Manila with her, pretending to be a couple.
When the family reunites, the sisters express their concerns about CJ's abrupt decision to marry, offending him and prompting apologies. CJ accepts but asks them to behave when meeting his fiancée, Princess Bayag, and her family. At the Bayags' villa, Princess's parents ask CJ to sign a prenuptial agreement. Appalled, the sisters plan to stop the wedding. Bobbie suggests CJ is marrying out of desperation, and Teddie asks their housekeeper, Toti Marie, to introduce CJ to other girls, leading to a failed boys' night out. The next day, Tristan tells Bobbie to decide on their marriage by the time he returns from overseas.
Teddie and Frodo visit a Bayags' spa with an obscene tagline, suspecting anomalies. Teddie asks Frodo to use their services, and when he moans during the massage, she calls the police. They discover the "happy ending" refers to happy thoughts after a massage. Jeanette threatens to investigate the Salazars. CJ confronts his sisters about the incident, assuring them the wedding will proceed. Bobbie confronts Teddie, leading to an argument. Later, Bobbie sees Chad flirting with another woman while buying condoms. The next morning, Bobbie tells Alex, but they end up fighting.
The Bayags visit the Salazars to show the wedding gowns, which the Salazars dislike. Honey Boy suggests playing charades to decide the gowns. During the game, the Bayags hint that Teddie is a maid, prompting Grace to make them leave. Confronted by Grace, Teddie admits she was laid off during the recession and vents her emotions. Bobbie reveals her lifelong hurt and loneliness to Grace, leading Trixie to sympathize with her.
The next day, Alex and Bobbie reconcile, and Alex breaks up with Chad. Later, CJ informs his family of Princess's grandfather's death, prompting the two families to reconcile and apologize. Due to a superstition prohibiting weddings within a year of a family member's death, CJ and Princess's wedding is canceled. To avoid wasting the preparations and expenses, Bobbie marries Tristan instead, with the Salazars wearing the Bayags' gowns.
The film's soundtrack was Salamat, which was written by Christian Martinez, and performed by Richard Yap. The said song was also used in the celebration of Rebisco's (the film's sponsor) 50th anniversary.
On February 27, 2020, Star Cinema announced that the film will be getting a prequel entitled "Four Sisters Before the Wedding". The prequel will also be directed by Giselle Andres, an assistant director in the original film, however, Mae Cruz-Alviar replaced her instead, and it
will be set during the Salazar siblings' teenage years. The prequel will star Charlie Dizon, Alexa Ilacad, Gillian Vicencio, and Belle Mariano as Teddie, Bobbie, Alex, and Gabbie, respectively. It will be produced by SCX, a new sub-brand under ABS-CBN Films, Star Cinema.[7]