SR 206 begins at an intersection with SR 207 in Spuds, near Deep Creek, a small tributary of the St. Johns River. From there, SR 206 travels east through uninhabited farmland, crossing Interstate 95 (I-95). East of I-95, the road is mostly uninhabited, but establishments slowly emerge, especially east of US 1 in Dupont Center. SR 206 continues east through a partially established residential area before crossing the Intracoastal Waterway, entering Crescent Beach and terminating at SR A1A.[2]