Ashley Sarmiento as Flor M. Maristela – Ida and Crisanto's daughter, Arnold and Beth's stepdaughter, and Liza's half-sister.
Rhed Bustamante as Liza P. Maristela – Beth and Crisanto's daughter, and Flor's half-sister.
Jolina Magdangal as Florida "Ida" Malubay-Magsakay — Crisanto's ex-mistress and Flor's mother.
Marvin Agustin as Crisanto Maristela — Flor & Liza’s father, Beth's husband, and Ida's ex-lover.
Desiree del Valle as Elizabeth "Beth" S. Perez-Maristela — Crisanto’s wife, Liza’s mother, and Flor's stepmother.
Carlo Aquino as Arnold Magsakay — Florida's husband and Flor's stepfather.
Valerie Concepcion as Teacher Daisy C. Hizon — Flor and Liza's dance teacher who has an obsession over Flor and Crisanto. Recruits Liza into her plans by emotionally manipulating her into believing her parents love Flor more than her.
Supporting cast
Elizabeth Oropesa as Lorena Sanchez-Perez — Beth's mother, Liza's grandmother, and Flor's stepgrandmother.
Tetchie Agbayani as Teresa Malubay — Florida's mother and Flor's grandmother.
Juan Rodrigo as Mariano "Nano" Perez — Beth's father, Liza's grandfather, and Flor's stepgrandfather who is a lung cancer survivor.
Tess Antonio as Annie — The rude, talkative, argumentative, and overly dramatic housemaid of the Maristela family. She prefers Flor more than Liza.
Joey Paras as Rona — Beth's best friend who constantly argues with Annie.
Edward Mendez as Manuel "Manny" S. Perez — Beth's unemployed younger brother.
Lemuel Pelayo as Jojo S. Perez — Beth's youngest brother.
Johan Santos as Miguel Fontanillas — Crisanto's friend.
Ronie "Atak" Arañia as Buslog Malubay — Teresa's adoptive son.
Dionne Monsanto as Lynette Nacianceno-Perez — Manny's kindhearted wife.
Lee Robin Salazar as Col. Francisco — Crisanto's best friend who was killed by the rebels.
Debraliz Borres as Bebeng Magsakay — Arnold's aunt.
Michael "Eagle" Riggs as Mama Wanda — Arnold's boss and the owner of the gay bar that Arnold works at.
Ricky Rivero as Lawrence "Lolei" Alcantara — Arnold's kindhearted customer from the gay bar who helps with his finances.
Wilma Doesnt as Dalisay Sulta — The manager of Lolei's department store.
JC Santos as Jason — Arnold's workmate who despises him.
Marco Pingol as Travis Marquez — Flor and Liza's neighbor and friend.
Bugoy Cariño as Luke Marquez — Travis' older brother, Flor and Liza's neighbor who is also their friend.
Carlo Maceda as Gener De Jesus — a man with a learning disability. He later befriends Flor.
JC Movido as Jenjen — Jason's autistic daughter.
Juvy Lyn Bison as Jenny Perez — Manny and Lynette's daughter.
Miguelito de Guzman as JC Perez — Manny and Lynette's son.
Guest cast
Kiko Matos as Cornelio Maristela — Crisanto's brother, who joined the rebels.
Initially meant to be part of ABS-CBN's PrimeTanghali noontime block, FlordeLiza was originally planned to replace Give Love on Christmas before It's Showtime. However, in a last minute change, the timeslot was moved to be part of ABS-CBN's Kapamilya Gold afternoon block. The timeslot was after It's Showtime. Oh My G! was the one who took the timeslot before It's Showtime. It was moved to ABS-CBN's PrimeTanghali noontime block instead of the Primetime Bida evening block which the original timeslot is before TV Patrol which was the original plan.
It aired reruns on Jeepney TV from January 1 to April 19, 2018; March 28 to October 3, 2020; and March 17 to September 28, 2024.
