Flavin-containing amine oxidoreductase

Flavin-containing amine oxidoreductases are a family of various amine oxidases, including maize polyamine oxidase (PAO),^[2] L-amino acid oxidases (LAO) and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. In vertebrates, MAO plays an important role in regulating the intracellular levels of amines via their oxidation; these include various neurotransmitters, neurotoxins and trace amines.^[3] In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium.^[4] PAOs in plants, bacteria and protozoa oxidise spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines.^[2] Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid-binding proteins, and antibacterial glycoproteins.

Human proteins containing this domain

AOF1; AOF2; IL4I1; MAOA; MAOB; PAOX; PPOX; SMOX;

References

^ Binda C, Coda A, Angelini R, Federico R, Ascenzi P, Mattevi A (March 1999). "A 30-angstrom-long U-shaped catalytic tunnel in the crystal structure of polyamine oxidase". Structure. 7 (3): 265–76. doi:10.1016/s0969-2126(99)80037-9. PMID 10368296.
^ ^a ^b Schinina ME, Mariottini P, Tavladoraki P, Cecconi F, Manera F, Rea G, Federico R, Angelini R, Di Agostino S (1998). "Maize polyamine oxidase: primary structure from protein and cDNA sequencing". FEBS Lett. 426 (1): 62–66. doi:10.1016/S0014-5793(98)00311-1. PMID 9598979. S2CID 41885430.
^ Tsugeno Y, Ito A (1997). "A key amino acid responsible for substrate selectivity of monoamine oxidase A and B". J. Biol. Chem. 272 (22): 14033–14036. doi:10.1074/jbc.272.22.14033. PMID 9162023.
^ Lerch K, Schilling B (1995). "Cloning, sequencing and heterologous expression of the monoamine oxidase gene from Aspergillus niger". Mol. Gen. Genet. 247 (4): 430–438. doi:10.1007/BF00293144. PMID 7770050. S2CID 26600138.

This article incorporates text from the public domain Pfam and InterPro: IPR002937

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