The First Church of Christ, Scientist, in Boston, Massachusetts, U.S., is the administrative headquarters and mother church of the Church of Christ, Scientist.

First Church of Christ, Scientist may also refer to:

• A church in Bowral, New South Wales
• First Church of Christ, Scientist, Brisbane, Queensland
• A church in North Terrace, Adelaide, South Australia
• A church in Ringwood, Victoria
• First Church of Christ, Scientist, Perth, Western Australia

• First Church of Christ, Scientist (North Vancouver), British Columbia
• First Church of Christ, Scientist (Ottawa), Ontario
• First Church of Christ, Scientist (Toronto), Ontario

• First Church of Christ, Scientist (Hong Kong), listed under List of Grade II historic buildings in Hong Kong.

• First Church of Christ, Scientist (Brighton)
• First Church of Christ, Scientist, Richmond, London
• Cadogan Hall, building formerly First Church of Christ, Scientist, London

• First Church of Christ, Scientist (Phoenix, Arizona)

• First Church of Christ, Scientist (Little Rock, Arkansas)

• First Church of Christ, Scientist (Berkeley, California)
• First Church of Christ, Scientist (Long Beach, California)
• First Church of Christ, Scientist (Los Angeles, California)
• First Church of Christ, Scientist (Riverside, California)

• First Church of Christ, Scientist (Denver, Colorado), a Denver Landmark

• First Church of Christ, Scientist (Cocoa, Florida)
• First Church of Christ, Scientist (Miami, Florida)
• First Church of Christ, Scientist (Orlando, Florida)
• First Church of Christ, Scientist (St. Petersburg, Florida)
• First Church of Christ, Scientist (West Palm Beach, Florida)

• First Church of Christ, Scientist (Atlanta)

• First Church of Christ, Scientist (Chicago, Illinois)
• First Church of Christ, Scientist (Rock Island, Illinois)

• First Church of Christ, Scientist (Davenport, Iowa)
• First Church of Christ, Scientist (Fairfield, Iowa)
• First Church of Christ, Scientist (Grinnell, Iowa)
• First Church of Christ, Scientist (Marshalltown, Iowa)
• First Church of Christ, Scientist (Mason City, Iowa)

• First Church of Christ, Scientist (Huntington, Indiana)

• First Church of Christ, Scientist (Baltimore, Maryland)

• First Church of Christ, Scientist (Cambridge, Massachusetts)
• First Church of Christ, Scientist (Dedham, Massachusetts)
• First Church of Christ, Scientist (Newton, Massachusetts)

• Hilberry Theatre (Wayne State University), building formerly First Church of Christ, Scientist (Detroit)
• Temple Beth Sholom (Marquette, Michigan), building formerly First Church of Christ, Scientist (Marquette, Michigan)

• First Church of Christ, Scientist (Fairmont, Minnesota)
• First Church of Christ, Scientist, Albion Avenue (Fairmont, Minnesota)
• First Church of Christ Scientist (Minneapolis, Minnesota)

• First Church of Christ, Scientist (St. Louis, Missouri)

• First Church of Christ, Scientist (Vicksburg, Mississippi)

• First Church of Christ, Scientist (Reno, Nevada)

• First Church of Christ, Scientist (New York City)

• First Church of Christ, Scientist (New Bern, North Carolina)

• First Church of Christ, Scientist (Cleveland, Ohio)
• First Church of Christ, Scientist (Elyria, Ohio)
• First Church of Christ, Scientist (Lakewood, Ohio)
• First Church of Christ, Scientist (Lebanon, Ohio)
• First Church of Christ, Scientist (Sandusky, Ohio)
• First Church of Christ, Scientist (Toledo, Ohio)

• First Church of Christ, Scientist (Oklahoma City)

• First Church of Christ, Scientist (Forest Grove, Oregon)
• First Church of Christ, Scientist (Portland, Oregon)

• First Church of Christ, Scientist (Mt. Lebanon, Pennsylvania)
• First Church of Christ, Scientist (Pittsburgh, Pennsylvania)
• First Church of Christ, Scientist (Scranton, Pennsylvania)

• First Church of Christ, Scientist (Paris, Texas)

• First Church of Christ Scientist (Salt Lake City, Utah)

• First Church of Christ, Scientist (Seattle)
• First Church of Christ, Scientist (Tacoma, Washington)

• First Church of Christ, Scientist (Madison, Wisconsin)
• First Church of Christ, Scientist (Milwaukee, Wisconsin)
• First Church of Christ, Scientist (Neillsville, Wisconsin)
• First Church of Christ, Scientist (Oconto, Wisconsin)

• Church of Christ, Scientist
• First Church of Christ (disambiguation)
• Second Church of Christ, Scientist (disambiguation)
• Third Church of Christ, Scientist (disambiguation)
• Fourth Church of Christ, Scientist (disambiguation)
• Fifth Church of Christ, Scientist (disambiguation)
• Sixth Church of Christ, Scientist (disambiguation)
• Eighth Church of Christ, Scientist
• Seventeenth Church of Christ, Scientist
• List of former Christian Science churches, societies and buildings