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Fexlamose

Fexlamose
Clinical data
Other namesAER-01; MUC-031
Identifiers
  • (2S,3S,4S,5R,6R)-2-(sulfanylmethyl)-6-[(2R,3R,4S,5S,6S)-3,4,5-trihydroxy-6-(sulfanylmethyl)oxan-2-yl]oxyoxane-3,4,5-triol
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC12H22O9S2
Molar mass374.42 g·mol−1
3D model (JSmol)
  • C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CS)O)O)O)O)O)O)S
  • InChI=InChI=1S/C12H22O9S2/c13-5-3(1-22)19-11(9(17)7(5)15)21-12-10(18)8(16)6(14)4(2-23)20-12/h3-18,22-23H,1-2H2/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-/m1/s1
  • Key:LVLYFBOCRJBHIZ-LIZSDCNHSA-N

Fexlamose is an investigational new drug that is being developed by Aer Therapeutics for the treatment of chronic obstructive pulmonary disease. It is mucolytic agent that contains a thiol linked to a saccharide that undergoes thiol–disulfide exchange with mucin disulfide bridges thereby breaking those bonds between mucin subunits and reducing the viscosity of mucin.[1][2]

References

  1. ^ "Fexlamose". AdisInsight. Springer Nature Switzerland AG. Retrieved 3 July 2026.
  2. ^ Cazzola M, Rogliani P, Ora J, Calzetta L, Matera MG (April 2026). "Mucus as a Treatable Trait in Chronic Airway Diseases". Drugs. 86 (4): 443–463. doi:10.1007/s40265-026-02294-1. PMC 13005781. PMID 41712061.
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