FGF-1 internal ribosome entry site (IRES)

FGF-1 internal ribosome entry site (IRES)
Predicted secondary structure and sequence conservation of IRES_FGF1
Identifiers
SymbolIRES_FGF1
RfamRF00387
Other data
RNA typeCis-reg; IRES
Domain(s)Eukaryota
GOGO:0043022
SOSO:0000243
PDB structuresPDBe

The FGF-1 internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of fibroblast growth factor 1 and allows cap-independent translation. It is thought that FGF-1 internal ribosome entry site (IRES) activity is strictly controlled and highly tissue specific.[1]

References

  1. ^ Martineau Y, Le Bec C, Monbrun L, Allo V, Chiu IM, Danos O, Moine H, Prats H, Prats AC (September 2004). "Internal ribosome entry site structural motifs conserved among mammalian fibroblast growth factor 1 alternatively spliced mRNAs". Molecular and Cellular Biology. 24 (17): 7622–7635. doi:10.1128/MCB.24.17.7622-7635.2004. PMC 507008. PMID 15314170.
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